About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

New Pathway to Reduce Cocaine’s Effect on Cardiovascular System Identified

by Colleen Fleiss on February 27, 2018 at 12:39 AM
Font : A-A+

New Pathway to Reduce Cocaine’s Effect on Cardiovascular System Identified

New research published in the American Heart Association's journal Hypertension identifies the role of miR-30c-5p in cocaine-related cardiovascular disease.

Reactive oxygen species is a type of unstable molecule that contains oxygen and that easily reacts with other molecules in a cell. A buildup of reactive oxygen species in cells may cause damage to DNA, RNA and proteins and may cause cell death.

Advertisement


The team determined that cocaine activates the molecule microRNA (miR)-30c-5p, increasing ROS levels in the cardiovascular system. But, blocking activation of miR-30c-5p dramatically reduced cocaine-induced cardiovascular impacts.

"The biggest surprise to us was that the modulation of a single miRNA-mRNA pathway could have such a profound effect on cardiovascular function," says Chunming Dong, M.D., study senior author and professor of medicine at University of Miami School of Medicine. "This also suggests that targeting this one pathway may have significant therapeutic benefit, which is an exciting possibility."
Advertisement

In the study, mice injected with cocaine had high blood pressure, stiff blood vessels and excess levels of ROS -- all indications of cardiovascular disease. Cocaine exposure also increased levels of the miR-30c-5p molecule in the mice. When the researchers treated the mice to block the increase in miR-30c-5p, the mice did not show high blood pressure, stiffer blood vessels or elevated ROS levels when given cocaine.

The team plans to test the findings to see if they are observed in patients to determine the viability of this targeted pathway.

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
Turmeric: Magic Ingredient to Keep you Healthy in Winter
Top 7 Benefits of Good Oral Hygiene
Healthy and Safer Thanksgiving 2021
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.


Recommended Reading
Recreational Drugs are not Completely Safe
Recreational drugs are commonly used in rave parties. Serotonin syndrome can occur in patients ......
Impact of Drug Abuse on Health and Society
Drug abuse is a negative social trend that pushes youth to drug addiction in the pretext of getting ...
Hybrid Heart Surgery - Surgical Procedure
Hybrid heart surgery combines cardiac surgery with catheter-based approach. Hybrid cardiac surgery ....
Mitochondria Linked to Cocaine Addiction can be Blocked
Mitochondria in brain cells that cause brain disease were found to be linked to cocaine addiction .....

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use