About Careers Internship MedBlog Contact us

New Molecules Inhibit Clotting Disorders

by VR Sreeraman on November 10, 2007 at 1:20 PM
Font : A-A+

New Molecules Inhibit Clotting Disorders

Researchers at the Virginia Commonwealth University (VCU) have identified new molecules that inhibit clotting disorders.

The researchers discovered that the identified molecules binded with Thrombin (exosite II) and inhibited the mechanism of a key enzyme that played a vital role in clotting disorders which could lead to novel therapies to treat clots in the lungs and those localized deep in the body in areas such as the legs.


According to the study, Antithrombotic disorders occur when the effect of thrombin, a protein involved in coagulation, is inhibited, rendering blood unable to clot effectively. These disorders, which are considered common, could prove to be fatal. Additionally, clotting disorders arise due to complications from other diseases like cancer.

The study was designed of three highly complex molecules with unique anticoagulant properties that were prepared in the laboratory. These molecules, known as sulfated DHPs, were completely different from anticoagulants used in the clinic today including heparins, coumarins and hirudins.

The researchers established that the molecules were able to inhibit the ability of critical enzymes involved with the cascade of events involved in blood clotting. Specifically, the molecules prevented the normal action of thrombin and factor Xa, which were the critical enzymes targeted by current anticoagulant therapy.

"We have identified a new mechanism that may prevent clotting. This approach may result in new drugs for the treatment of thrombotic disorders, including pulmonary embolism, deep vein thrombosis and more," said Umesh R. Desai, Ph.D., a professor in the Department of Medicinal Chemistry at the VCU School of Pharmacy

"The molecules we have designed may possess several advantages compared to currently available anticoagulation drugs. "For example, new anti-clotting therapies may result in reduced hospital stays for patients, fewer side effects, and possibly an overall cost reduction in therapy because our molecules are likely to be synthesized in an inexpensive manner," he added.

Desai and his team have now taken up the task of investigating the unit or units in the complex molecule responsible for the anti-clotting activity.

The research was supported by grants from the National Institutes of Health and the American Heart Association National Center and appeared in the Nov. 2 issue of the Journal of Biological Chemistry.

Source: ANI


Latest General Health News

What Are the Consequences of Celebrities Endorsing Tobacco?
In India, youth must be aware of the diseases linked to cigarette smoking and tobacco consumption, causing a form of healthcare emergency.
 People Living Close to the Seaside Enjoy Better Health
Direct coastal access may represent a viable route to public health promotion, but the relationships of coastal living are not strongest among lower-income groups.
 Over Four Million Gardeners Place Their Hearing in Danger
New research by Tinnitus UK has found that over four million gardeners are putting their hearing capacity at risk this summer without using safety protection.
Breaking the Barrier: Unraveling Mucus Plugs to Save Lives in COPD
Mucus plugs could be targeted to help reduce fatalities from chronic obstructive pulmonary disease.
 Disease Modifying Therapies for Multiple Sclerosis Continue to Drive Up Healthcare Cost
The development of reliable curative therapies for multiple sclerosis could significantly reduce the economic burden of the disease on patients and wider society.
View All
This site uses cookies to deliver our services.By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use  Ok, Got it. Close

New Molecules Inhibit Clotting Disorders Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests