The thyroid gland has an important role in determining how much energy the body burns. Thyroid gland functions are regulated by a hormone known as thyroid-stimulating hormone (TSH). Increased levels of TSH, as well as increased signaling through the receptor for TSH, result in hyperthyroidism and goiter. Signals downstream of the receptor for TSH had been thought to be mediated mainly by a protein complex known as Gs. But now, a study that appears online on August 9, in advance of publication in the September print issue of the Journal of Clinical Investigation, indicates that in mice Gq/G11-mediated signaling has an essential role in transmitting TSH-induced signals and therefore in regulating thyroid gland function. This makes Gq and G11 potential new targets for the treatment of hyperthyroidism and goiter. In the study, Stefan Offermanns and colleagues from the University of Heidelberg, Germany, generated mice lacking the alpha-subunits of both Gq and G11 only in cells of the thyroid gland. These mice had reduced thyroid gland function and many had symptoms similar to individuals with hypothyroidism. In addition, the thyroid gland in these mice was unresponsive to the proliferative effects of TSH and a goitrogenic diet. The authors therefore suggest that inhibiting Gq and G11, or the molecules activated downstream of these G proteins, might be of therapeutic benefit for individuals with diseases characterized by increased thyroid gland function and/or growth. Source: EurekalertSRM/M << Winehouse Describes Her Drug Overdose as the Most Terrifying... A Peek into Lohan’s Costly Third Rehab Stint >> Recommended Reading Hyperthyroidism Hyperthyroidism is a condition in which the thyroid gland makes excessive thyroid hormone. Grave's disease is the most common cause of hyperthyroidism. READ MORE Thyroid function test A butterfly like gland with two lobes extending around trachea and produces thyroxine.It exists as total T4,T3,free T4 and TSH.It affects cellular growth and metabolism. READ MORE Iodine Deficiency Disorder To control IDD, the 'National Goiter Control Program (NGCP)' was launched which was later renamed as the 'National Iodine Deficiency Disorder Control Program (NIDDCP)'. READ MORE Bulging Eyes Bulging Eyes is the abnormal protrusion or sticking out of one or both eyeballs from the eye socket. It is most often caused by Grave’s disease and results in corneal dryness, weakening eyesight and even blindness. READ MORE Can Drugs Affect Thyroid Function? Some medications affect the normal function of thyroid gland leading to thyroid function disorders in the form of hypothyroidism or hyperthyroidism. Read Patient Information Leaflet of medications to be aware of such effects and conduct regular monitoring of thyroid function to avoid complications READ MORE Glycosuria Glycosuria is an indication of elevated blood glucose levels and a condition in which excess glucose is excreted in the urine. READ MORE Goitre (Thyroid Swelling) Goitre is an enlargement of the thyroid gland. Autoimmune diseases, hereditary factors, iodine deficiency cause goitre. READ MORE Postpartum Thyroiditis Postpartum thyroiditis is an autoimmune thyroid disorder where the levels of thyroid hormone are abnormal within a year following childbirth. READ MORE Screening Tests for Thyroid Dysfunction High or low thyroid stimulating hormone (TSH) level is indicative of a dysfunctional thyroid. READ MORE Thyroid Cancer “Shaped like a butterfly she sits within the neck,” that’s what an anonymous poet wrote about the thyroid gland but it can become cancerous and spread to other parts. READ MORE Most Popular on Medindia Vent Forte (Theophylline) Blood - Sugar Chart Turmeric Powder - Health Benefits, Uses & Side Effects More News on: HyperthyroidismThyroidThyroid CancerScreening Tests for Thyroid DysfunctionGlycosuriaPostpartum ThyroiditisGoitre (Thyroid Swelling)Bulging EyesCan Drugs Affect Thyroid Function?