The thyroid gland has an important role in determining how much energy the body burns. Thyroid gland functions are regulated by a hormone known as thyroid-stimulating hormone (TSH). Increased levels of TSH, as well as increased signaling through the receptor for TSH, result in hyperthyroidism and goiter.
Signals downstream of the receptor for TSH had been thought to be mediated mainly by a protein complex known as Gs. But now, a study that appears online on August 9, in advance of publication in the September print issue of the Journal of Clinical Investigation, indicates that in mice Gq/G11-mediated signaling has an essential role in transmitting TSH-induced signals and therefore in regulating thyroid gland function. This makes Gq and G11 potential new targets for the treatment of hyperthyroidism and goiter.
Hyperthyroidism
Hyperthyroidism is a condition in which the thyroid gland makes excessive thyroid hormone. Grave's disease is the most common cause of hyperthyroidism.
In the study, Stefan Offermanns and colleagues from the University of Heidelberg, Germany, generated mice lacking the alpha-subunits of both Gq and G11 only in cells of the thyroid gland. These mice had reduced thyroid gland function and many had symptoms similar to individuals with hypothyroidism. In addition, the thyroid gland in these mice was unresponsive to the proliferative effects of TSH and a goitrogenic diet. The authors therefore suggest that inhibiting Gq and G11, or the molecules activated downstream of these G proteins, might be of therapeutic benefit for individuals with diseases characterized by increased thyroid gland function and/or growth.
SRM/M
Thyroid function test
A butterfly like gland with two lobes extending around trachea and produces thyroxine.It exists as total T4,T3,free T4 and TSH.It affects cellular growth and metabolism.
 Iodine Deficiency DisorderTo control IDD, the 'National Goiter Control Program (NGCP)' was launched which was later renamed as the 'National Iodine Deficiency Disorder Control Program (NIDDCP)'. | Advertisement
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