Drugs prescribed for various medical conditions can cause harmful liver side effects. Lab experiments with liver cells can help reveal the underlying molecular mechanisms by which these drugs cause liver damage, which could inform better prevention and treatment efforts. However, lab experiments alone cannot reliably predict actual effects in living patients.To improve translation of lab data to patients, Christoph Thiel of RWTH Aachen University, Germany, and colleagues recently developed a new strategy that uses computational modeling to simulate how liver cells in the body respond to different doses of different drugs. The approach integrates experimental observations with knowledge of how drugs are distributed and metabolized after they enter the body. The researchers had previously demonstrated their approach in a proof-of-concept study. In the new study, the approach was applied to simulate and compare the potentially toxic liver effects of fifteen different drugs at clinically relevant doses. ‘A computational modeling approach has been used by researchers to analyze and compare the toxic effects of fifteen different drugs on the liver.’ The scientists developed whole-body models to simulate the fate of each drug after ingestion and validated the models using experimental data from scientific literature. These models were then coupled with lab data to predict each drug's effects on the liver at patient level. The researchers found that the drugs fell into different groups that caused similar responses, including which genes would be transcribed in response to toxic doses. While further validation is required, the method has the potential to lead to faster diagnosis of toxic liver side effects in patients. It could help reveal which gene transcripts could serve as early signs of toxicity and which drug combinations might be particularly dangerous, for both new and existing drugs. "Consistently applied to the design of clinical development programs, the approach presented has the potential to early identify medical and economic risks of new drugs," says study co-author Lars Kuepfer. Source: Eurekalert << Novel Model Assesses Cost, Effectiveness of Interventions f... New Policies to Enable Earlier Detection of Autism in Child... >> Recommended Reading Capsaicin Reduces Activation of Hepatic Stellate Cells Preventing Liver Damage Eating capsaicin, the active compound of chili peppers, partially improved liver damage condition mice and inhibited further progression of the injury. READ MORE Weight-loss Surgery may Help Reduce Liver Damage Those affected by nonalcoholic fatty liver disease can benefit by bariatric surgery which is best known to help obese patients lose weight. READ MORE Aerobic Fitness Can Prevent Alcohol-Induced Liver Damage Excessive alcohol consumption can lead to chronic liver problems such as fatty liver disease and cirrhosis. READ MORE New Drug Could Prevent Liver Damage in Alcoholics Liver damage is one of the most common problems associated with regular consumption of alcohol. READ MORE Current Treatments for Liver Cancer Current Treatments for Liver Cancer (also known as hepatoma or hepatocellular carcinoma) can result in complete cure of the disease if it is detected early. READ MORE Drug Toxicity Drug toxicity is an adverse reaction of the body towards a drug that results as a side effect of a drug, reaction to a drug or drug abuse. READ MORE Drugs Banned in India Several drugs are either banned or withdrawn after introduction in the market. READ MORE Fatty Liver Disease: A Growing Health Problem in India Non alcoholic fatty liver disease (NAFLD) is the leading cause of liver dysfunction worldwide and is a rapidly growing health problem in India. READ MORE Hepatitis A Hepatitis A is the most benign of the hepatitis viruses and usually has no long term side effects. Hepatitis A vaccine is available that is 95% effective in preventing the disease. READ MORE Living Donor Liver Transplant: What Are the Risks? The risk of dying as a result of a living donor liver segment removal is between 0.2-2.0%. The risk of morbidity is anywhere between 1.3% (in highly experienced centers) to 60%. READ MORE Milk Thistle Milk Thistle is a resourceful natural plant which has many medicinal benefits. In herbal medication milk thistle is used in cases of liver diseases. READ MORE Wilson's Disease This is a rare inherited systemic disorder of copper metabolism, affecting the liver mainly before other organs. READ MORE Most Popular on Medindia Drug Interaction Checker Indian Medical Journals Find a Hospital More News on: Drug ToxicityHepatitis ALiverWilson's DiseaseDrugs Banned in IndiaMilk ThistleCurrent Treatments for Liver CancerFatty Liver Disease: A Growing Health Problem in IndiaLiving Donor Liver Transplant: What Are the Risks?