About Careers MedBlog Contact us

New Method for Joining Complex Organic Molecules Like Olefins With Functional Groups or Heteroatoms

by Dr. Trupti Shirole on December 19, 2014 at 8:25 AM
Font : A-A+

 New Method for Joining Complex Organic Molecules Like Olefins With Functional Groups or Heteroatoms

Chemists at The Scripps Research Institute (TSRI) have invented a powerful method for joining complex organic molecules like olefins with heteroatoms or functional groups. This new method does not require the use of extreme temperatures or pressures, nor harsh chemicals. Therefore, portions of the building blocks used that are particularly fragile remain unaltered by the reaction. This method will have immediate application to pharmaceuticals, materials, and agricultural and fragrance chemistry.

Carbon-to-carbon coupling methods had certain limitations. They often failed if either of the starting compounds contains 'functional groups' (small, reactive regions) attached to their main structure; and also in the presence of 'heteroatoms' (non-carbon atoms such as nitrogen, oxygen and iodine). Functional groups that would be destroyed by other cross-coupling methods are totally unscathed when using our method


Research Associate Jinghan Gui said, "The reaction setup is easy. We use a simple iron catalyst, a commercially available silane and ethanol i.e., grain alcohol as the solvent; and we can do the reaction in an open flask, meaning that we don't need to exclude air or moisture." The research team demonstrated the robustness of their reaction by taking an unconventional approach and running it in vodka, gin, whiskey, tequila, beer and wine instead of pure alcohol.

Chemists have shown that their reaction can be used to make compounds that were previously either unpractical to synthesize or could not have been made at all. In their report they have described making more than 60 compounds with the new method.

The study is reported in the 'Nature'.

Source: Medindia


Latest General Health News

More Than 300 People on Texas-Mexico Cruise Ship Fall Sick
Over 300 people had fallen sick with illness caused by Norovirus on a US cruise ship, say authorities.
 No Smoking Day 2023: Ex-smokers in Wakefield Lead the Campaign
Ex-smokers in Wakefield have shared their stories to encourage others to give up cigarettes on No Smoking Day 2023 which falls on 8th March.
New Protein Linked to Neurodegeneration
Total levels of m6A in the nervous system rise with age and that (some) neurodegenerative diseases are characterized by RNA hypermethylation.
How Stress Disrupts Maturation of Brain's Reward Circuits?
New study provides insights into the impact of early-life adversity on brain development and on control of reward behaviors that underlie emotional disorders
 Indonesia Partners With FIND for Diagnostic Testing Access Initiative
Ministry of Health of the Republic of Indonesia signed a formal memorandum of understanding (MOU) that will expand access to essential diagnostics in the country.
View All
This site uses cookies to deliver our services.By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use  Ok, Got it. Close

New Method for Joining Complex Organic Molecules Like Olefins With Functional Groups or Heteroatoms Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests