New Mechanism Decoded to Help Quit Unwanted Thoughts

The ability to inhibit unwanted thoughts relies on a neurotransmitter, a chemical in the brain that allows messages to pass between nerve cells known as GABA.

Unwanted thoughts are an extremely common symptom of anxiety disorders. Anxiety is the type of mental health disorder that specifically causes negative thinking, and the inability to control the thoughts that come into your head. For some people, anxiety itself can be caused by these thoughts.

Scientists have identified a key chemical within the "memory" region of the brain that allows us to suppress unwanted thoughts. The findings showed that the ability to inhibit unwanted thoughts relies on a neurotransmitter -- a chemical within the brain that allows messages to pass between nerve cells -- known as GABA.

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‘The main "inhibitory" neurotransmitter in the brain, GABA concentrations, within the hippocampus predict people's ability to block the retrieval process and prevent thoughts and memories from returning.’

GABA is the main "inhibitory" neurotransmitter in the brain, and its release by one nerve cell can suppress activity in other cells to which it is connected.

GABA concentrations within the hippocampus -- brain area involved in memory -- predict people's ability to block the retrieval process and prevent thoughts and memories from returning.

The results may explain why people suffering from disorders such as anxiety, post-traumatic stress disorder (PTSD), depression, and schizophrenia often experience persistent intrusive thoughts, the researchers said.

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"Our ability to control our thoughts is fundamental to our well-being," said Michael Anderson, Professor at the University of Cambridge.

"When this capacity breaks down, it causes some of the most debilitating symptoms of psychiatric diseases: intrusive memories, images, hallucinations, ruminations, and pathological and persistent worries -- key symptoms of mental illnesses such as PTSD, schizophrenia, depression, and anxiety," Anderson added.

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In the research, published in the journal Nature Communications, the team used a task known as the "Think/No-Think", where participants learned to associate a series of words with a paired, but otherwise unconnected, word, for example ordeal/roach and moss/north. They were later asked to recall the associated word.

As the participants tried to inhibit their thoughts, the researchers observed that even within this sample of healthy young adults, people with less hippocampal GABA were less able to suppress hippocampal activity and as a result much worse at inhibiting unwanted thoughts.