About My Health Careers Internship MedBlogs Contact us

New Insights On How Malarial Parasites Break Through Red Blood Cell

by Rishika Gupta on February 21, 2018 at 6:55 PM
Font : A-A+

 New Insights On How Malarial Parasites Break Through Red Blood Cell

SERA6 and SUB1 proteins are essential for the malarial parasites to breakthrough the infected red blood cells and continue o to infect new ones finds a new study. The findings of this study are published in the Journal of Nature Microbiology.

When malaria parasites invade red blood cells, they form an internal compartment where they replicate many times before bursting out of the cell and infecting more cells.


In order to escape red blood cells, the parasites have to break through both the internal compartment and the red cell membrane.

The research team used genetic knockout experiments to show that a protein called SUB1 is essential for the parasite to break through the internal compartment, while SERA6 - which is activated by SUB1 - is essential for the parasite to break through the red blood cell membrane.

"Over 400,000 people die of malaria each year, and resistance to common antimalarial drugs is growing," says Professor Mike Blackman, Group Leader at the Francis Crick Institute, who led the research. "We're studying the deadliest malaria parasite, Plasmodium falciparum, to try to find new drug targets that work in a different way to existing treatments."

In the latest study, the team have identified two key proteins that malaria parasites need to escape red blood cells and infect fresh cells. The research was done in collaboration with the Proteomics Science Technology Platform at the Crick as well as scientists at Birkbeck College, King's College London and the London School of Hygiene & Tropical Medicine.

"We've already started collaborating with GSK to see if designing drugs that target these proteins could form the basis of a new antimalarial drug," says Dr. James Thomas, Crick postdoctoral scholar and joint first author of the paper.

Using analytical tools, the team then figured out how SERA6 breaks through the blood cell membrane. Crick Ph.D. student and joint first-author Michele Tan explains: "There is a strong chicken wire-like meshwork that sits under the red blood cell membrane to provide strength and support. We found that SERA6 cuts the chicken wire, causing the blood cell membrane to collapse and rip open so that the parasites can escape."

Source: Eurekalert

News A-Z
News Category
What's New on Medindia
Printed Temperature Sensors help with Continuous Temperature Monitoring
Health Benefits of Giloy
Breast Cancer Awareness Month 2021 - It's time to RISE
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Thalassemia Parkinsons Disease Surgical Treatment Blood in Stools - Symptom Evaluation Bombay Blood Group Babesiosis Methemoglobinemia 

Recommended Reading
How do Malarial Parasites Develop Drug Resistance in Our Bodies?
The parasite Plasmodium digests hemoglobin, the oxygen-carrying protein in the blood and converts .....
Pregnant Women's Defences Deceived by Camouflaged Malarial Parasites
Researchers from Rigshospitalet - Copenhagen University Hospital - and the University of Copenhagen ...
Indian and American Scientists Unravel Genetic Codes of Malarial Parasites
An international team of researchers have said that they have managed to unravel genetic codes of .....
HIV Drugs May Target Malarial Parasites in the Future
Scientists have discovered that drugs used to treat HIV may also one day become lifesaving drugs ......
Babesiosis is an infection caused by transmission of Babesia parasites from animals to humans. It ma...
Blood in Stools - Symptom Evaluation
Blood in stools results from bleeding that arises from any part of the digestive tract. Causes of bl...
Bombay Blood Group
Bombay blood group is a rare blood type in which the people have an H antigen deficiency. They can r...
Methemoglobinemia is a congenital or acquired blood disorder caused by an abnormal amount of methemo...
Thalassemia is an inherited blood disorder passed on through parental genes causing the body to prod...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use