New Insight into Drug-Induced Hearing Loss Prevention

The occurrence, treatment and prevention of ototoxicity (hearing loss induced by drugs and solvents) has been studied under a research by Pharmaceutical Interventions for Hearing Loss Working Group. The findings of the study are published in the journal Frontiers in Cellular Neuroscience. "We're trying to elevate ways for the human population to avoid losing this important sensation for experiencing and communicating with the world around us," said co-author Peter Steyger, Ph.D., a professor of otolaryngology/head and neck surgery in the OHSU School of Medicine in Portland, Oregon.

"Ototoxocity is a threat to hearing at any age and hearing loss remains a significant side effect of chemotherapy. This review highlights how far we've come in understanding that threat and provides us with a roadmap for developing more effective ways to recognize and address the problem," added co-author Jian Zuo, Ph.D., of the Department of Developmental Neurobiology at St. Jude Children's Research Hospital in Memphis, Tennessee.

In people, hearing cells don't regenerate so the loss is irreversible. That's why it is crucial to understand the mechanisms that affect hearing and how to prevent loss of hearing, Steyger said. The introductory editorial, "Moving toward a future free of ototoxicity," highlights the latest scientific research exploring how certain pharmaceuticals damage the inner ear while others can protect it. It also highlights the need for better monitoring and detection of hearing loss over time, especially among patients being treated with antibiotics.

"Many people don't admit they're losing their hearing until it's really bad," Steyger said.

Steyger, who lost hearing as a child after being treated with antibiotics for meningitis when 14 months old, noted that hearing loss affects a surprisingly large proportion of the population - rising from an estimated 1 in 500 newborns to as many as half of all people age 75 or older. The research encapsulated in the new e-book includes 22 scientific articles from 91 authors and represents the state of the science in both prevention and treatment of ototoxicity hearing loss. This e-book is available to all, free of charge.

"This compilation will help to propel our knowledge forward and underscore the need to better understand the dangers of ototoxicity. The DoD Hearing Center of Excellence is honored to host and mobilize this important effort," said Carlos Esquivel, M.D., co-author and a neurotologist and chief medical officer in the Clinical Care, Rehabilitation, and Restoration Branch of the DoD Hearing Center of Excellence at Joint Base San Antonio in Texas.

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Source-Eurekalert