Medindia
Advertisement

New Hydrogel Contact Lens May Treat Serious Eye Disease More Effectively

by Adeline Dorcas on March 13, 2019 at 12:02 PM

New Hydrogel Contact Lens May Treat Serious Eye Disease More Effectively
New hydrogel contact lens could be a viable therapeutic option for treating corneal melting. The findings of the study are published in the journal ACS Biomaterials Science & Engineering.

A team of researchers at the University of New Hampshire have created a hydrogel that could one day be made into a contact lens to more effectively treat corneal melting, a condition that is a significant cause for blindness worldwide.
Advertisement


The incurable eye disease can be initiated by a number of different causes such as autoimmune diseases (like rheumatoid arthritis, Lupus, or Stevens-Johnson syndrome), chemical burns, or even some surgical procedures (like LASIK and cataract procedures). The patient's cornea melts due to the uncontrolled production of certain zinc-dependent enzymes called matrix metalloproteinases (MMPs) by the patient's immune cells in the cornea. To help prevent this, the researchers developed a new hydrogel that deactivates those enzymes by removing the zinc ions.

"Most of the current MMP inhibitors used to treat this condition work by binding to the zinc ions within the MMPs," said Kyung Jae Jeong, assistant professor of chemical engineering at UNH.
Advertisement

"However, once injected into the body, the MMP inhibitors travel through the bloodstream and entire body and can cause severe side effects because they are binding with and deactivating the zinc ions in other tissue. Our hydrogel works entirely different because it is localized, just in the eye, and deactivates MMPs by eliminating the zinc ions from the cornea. And since it would be a contact lens, if there were any issues, the patient would simply remove it."

In their study, the UNH researchers, along with researcher Jung-Jae Lee from the University of Colorado Denver Campus, outline how the hydrogel deactivates MMP-1, MMP-2, and MMP-9 which are the major factors in corneal melting.

The research was done in vitro and ex vivo (on extracted cornea tissue) and suggests that the new hydrogel could be a viable therapeutic option for treating corneal melting.

The end goal is to make the hydrogel into a contact lens that would allow more localized treatment of the eye and avoid side effects in the rest of the body. There is a pending patent which has been filed by UNHInnovation, which advocates for, manages, and promotes UNH's intellectual property.

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
'Hybrid Immunity' may Help Elude COVID-19 Pandemic
Stroop Effect
Plant-Based Diet may Reduce the Risk of COVID-19
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Astigmatism Conjunctivitis Myopia hyperopia Nervous Tic Eye Vision LASIK Surgery Facts Allergy Eye Drops Keratoconus 

Recommended Reading
Corneal Ulcer
A corneal ulcer (ulcerative keratitis/eyesore) is an open sore on the cornea....
New Contact Lens Patch to Treat Eye Diseases Discovered
Newly discovered contact lens patch can help treat severe eye diseases such as glaucoma and macular ...
Eye Infection in Contact Lens Wearers May Cause Blindness
Are contact lenses safe? Contact lens wearers are warned of Acanthamoeba infection outbreak that ......
New 'bandage' Contact Lens can Treat Corneal Injuries
New therapeutic contact lens has been developed that acts as a bandage for eye surface injuries, ......
Allergy Eye Drops
Eye allergies are treated with different types of eye drops such as lubricants, antihistamines, NSAI...
Astigmatism
Astigmatism is a refractive error of the eye, which causes blurred or distorted vision. Astigmatism ...
Conjunctivitis
Conjunctivitis or Pink Eye causes redness and soreness of the conjunctiva and is responsible for 1% ...
Hyperopia
Long sightedness also known as hyperopia or farsightedness is a common vision problem. Long-sighted ...
Keratoconus
Keratoconus is a bilateral condition affecting both the eyes. Usually one eye is more severely affec...
Myopia
Myopia is the inability of a person to see the distant objects clearly. Myopia is also known as near...
Nervous Tic
Trigeminal Neuralgia or tic douloureux is one of the most painful nervous system disorders that affe...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use