A unique, hybrid bone implant has been developed by the researchers using a combination of two polymers that imitates the bone structure and is increasingly reinforced to provide strength and elasticity. The core of the implant is made up of porous ultra high molecular weight polyethylene, and the shell is made up of polyetherketone. The cost of the implant is expected to be much lower than that of analogs, according to the study published in Materials Letters.
Ultra high molecular weight polyethylene (UHMWPE) and polyetheretherketone (PEEK) are among the most frequently used materials in orthopedics. Each of them has a certain set of properties, and the choice of material is based mainly on what kind of bone defect should be eliminated. Thus, UHMWPE is traditionally used in joint replacement, and PEEK due to its greater strength, is mainly used in spinal surgery. Moreover, PEEK is a fairly expensive material, so it is used less often than UHMWPE.
Pagets And Jaw Bone Diseases
Osteitis deformans, or Pagets disease of the bone, is the deformity of the bone. Symptoms include severe bone pain, bowing of legs, deafness, facial paralysis and spinal deformities.
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‘The implant not only imitates the human bone, but the porous part will also allow the bone to penetrate the implant, which over time, will behave like a natural human bone.’
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Scientists from the Center of Composite Materials (NUST MISIS) applied the previously developed technology for the formation of porous biomimetic materials and conducted an experimental comparative analysis of the mechanical properties of modified UHMWPE and PEEK. As a result, they proposed a fundamentally new hybrid material that combines the useful properties of both polymers.
"We have been working with UHMWPE for quite a long period of time. Apparently, PEEK is relatively new for us. Due to the fact that we were trying to imitate natural porous bone structure in implants made of UHMWPE, we decided to also do this with PEEK. Next, we tested and compared the compression properties of the materials" - Fedor Senatov, PhD, head of the research group.
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However, the high hardness of the PEEK had a negative impact on the porous modification of the material: although PEEK demonstrated good properties at compression test, it was found that when cutting (and during installation of the implant surgeon is required to "adjust" it under the edge of the defect) it starts to crumble. Crumbs in the area of implantation are unacceptable, so scientists decided to try to create a hybrid that would retain only the beneficial properties of both polymers. This is especially interesting from the point of view of imitation of the structure of the bone itself, because in the core (trabecular part) it is just softer, and on the shell (cortical part) is harder.
"We have created a hybrid cylindrical implant, which core and shell are made of soft porous UHMWPE and hard non-porous PEEK respectively. Tests of the mechanical strength of the implant showed that its characteristics almost completely correspond to the normal human bone: the trabecular bone has elastic modulus from 0.001 GPa to 0.002 GPa, and the porous UHMWPE has about 0.002 GPa; cortical bone has elastic modulus about 11 GPa, and PEEK has about 9 GPa" - Alexander Chubrik, 4th year student, co-author of the research.
The imitation of the human bone is not the only advantage of the implant: moreover, the porous part will allow the bone to "penetrate" the implant. This means that over time, the fixing plates can be removed, and the implant will already behave as a bone. In addition, due to the fact that the consumption of PEEK will decrease, such implants will be more affordable.
Scientists proceed the research in two directions: they test the hybrid material in vivo, and work on the attaching bioceramics to the implant surface to accelerate regeneration in the replaced bone area.
Source: Eurekalert
Bone Cancer
Find the facts of bone cancer including types of bone cancer, symptoms, causes, treatment, diagnosis and more information.
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However, the high hardness of the PEEK had a negative impact on the porous modification of the material: although PEEK demonstrated good properties at compression test, it was found that when cutting (and during installation of the implant surgeon is required to "adjust" it under the edge of the defect) it starts to crumble. Crumbs in the area of implantation are unacceptable, so scientists decided to try to create a hybrid that would retain only the beneficial properties of both polymers. This is especially interesting from the point of view of imitation of the structure of the bone itself, because in the core (trabecular part) it is just softer, and on the shell (cortical part) is harder.
"We have created a hybrid cylindrical implant, which core and shell are made of soft porous UHMWPE and hard non-porous PEEK respectively. Tests of the mechanical strength of the implant showed that its characteristics almost completely correspond to the normal human bone: the trabecular bone has elastic modulus from 0.001 GPa to 0.002 GPa, and the porous UHMWPE has about 0.002 GPa; cortical bone has elastic modulus about 11 GPa, and PEEK has about 9 GPa" - Alexander Chubrik, 4th year student, co-author of the research.
The imitation of the human bone is not the only advantage of the implant: moreover, the porous part will allow the bone to "penetrate" the implant. This means that over time, the fixing plates can be removed, and the implant will already behave as a bone. In addition, due to the fact that the consumption of PEEK will decrease, such implants will be more affordable.
Scientists proceed the research in two directions: they test the hybrid material in vivo, and work on the attaching bioceramics to the implant surface to accelerate regeneration in the replaced bone area.
Source: Eurekalert
Bone Marrow Aspiration and Biopsy
Bone marrow biopsy and aspiration is the removal of some bone marrow tissue for diagnosis and management of cancers of blood cells and multiple myeloma.
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 Bone Marrow TransplantationPreferred Term is Hematopoietic stem cell transplantation. In this stem cell from bone marrow are injected into a recipient after treating them with growth factor. | Advertisement
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