A new research has shed light on a genome and has revealed new genes that are involved in forming long-term memories.
The study conducted in c. Elegans worms at Princeton University aimed at finding ways to retain cognitive abilities during aging.
Osteogenesis Imperfecta
Encyclopedia section of Medindia gives general info about Osteogenesis Imperfecta
Advertisement
Senior author Coleen Murphy, an associate professor of molecular biology and the Lewis-Sigler Institute for Integrative Genomics at Princeton University, said that the study identified more than 750 genes involved in long-term memory, including many that had not been found previously and that could serve as targets for future research.
Murphy said that there is a pretty direct relationship between CREB (cAMP-response element-binding protein) and long-term memory and many organisms lose CREB as they age and by studying the CREB-activated genes involved in long-term memory, the researchers hope to better understand why some organisms lose their long-term memories as they age.
![Cardiac Markers]( "Cardiac Markers")
Cardiac markers are biomarkers which are measured to evaluate the function of heart. The test for troponin may be regarded as the most sensitive and specific test for myocardial
To identify the genes, the researchers first instilled long-term memories in the worms by training them to associate meal-time with a butterscotch smell. Trained worms were able to remember that the butterscotch smell means dinner for about 16 hours, a significant amount of time for the worm.
The researchers then scanned the genomes of both trained worms and non-trained worms, looking for genes turned on by CREB.
The researchers detected 757 CREB-activated genes in the long-term memory-trained worms, and showed that these genes were turned on primarily in worm cells called the AIM interneurons.
The researchers also found CREB-activated genes in non-trained worms, but the genes were not turned on in AIM interneurons and were not involved in long-term memory. CREB turns on genes involved in other biological functions such as growth, immune response, and metabolism. Throughout the worm, the researchers noted distinct non-memory (or "basal") genes in addition to the memory-related genes.
The study was published in the journal Neuron.
Source: Medindia
Cardiac Markers
Cardiac markers are biomarkers which are measured to evaluate the function of heart. The test for troponin may be regarded as the most sensitive and specific test for myocardial
Advertisement
To identify the genes, the researchers first instilled long-term memories in the worms by training them to associate meal-time with a butterscotch smell. Trained worms were able to remember that the butterscotch smell means dinner for about 16 hours, a significant amount of time for the worm.
The researchers then scanned the genomes of both trained worms and non-trained worms, looking for genes turned on by CREB.
The researchers detected 757 CREB-activated genes in the long-term memory-trained worms, and showed that these genes were turned on primarily in worm cells called the AIM interneurons.
The researchers also found CREB-activated genes in non-trained worms, but the genes were not turned on in AIM interneurons and were not involved in long-term memory. CREB turns on genes involved in other biological functions such as growth, immune response, and metabolism. Throughout the worm, the researchers noted distinct non-memory (or "basal") genes in addition to the memory-related genes.
The study was published in the journal Neuron.
Source: Medindia
Genetic Testing of Diseases
Genetic testing helps to confirm a genetic condition in an individual and involves q complex laboratory techniques
Advertisement
Advertisement
Recommended Reading
Latest Research News
The International Space Station will be used to carry out experiments seeking to improve understanding of incurable child brain tumors and the muscle aging process.
How many people in the UK have misophonia? In a representative sample study, most people had at least some irritation upon hearing trigger sounds.
Routine eye-checkups and mass screenings enable early diagnosis and treatment of glaucoma. Late-stage glaucoma diagnosis leads to blindness.
Brain plasticity following blindness leads to superior ability in sensing signals from the heart, which has implications for bodily awareness and emotional processing.
A group of scientists were awarded £1.3 million to create a new “point of care testing” kit that detects Alzheimer's disease biomarkers.
