About My Health Careers Internship MedBlogs Contact us

New Experimental Drug Helps Treat Antibiotic Resistant Bacteria

by Aishwarya Nair on December 3, 2020 at 3:29 PM
Font : A-A+

New Experimental Drug Helps Treat Antibiotic Resistant Bacteria

An experimental drug being tested to treat neurodegenerative disease may help fight against life-threatening antibiotic resistant bacteria, suggests a study from Australia.

Bacterial resistance to antibiotics is growing as a worldwide problem. Handling this crisis is getting difficult day by day. Enterobacterales (gram negative bacteria like, E.coli, Klebsiella pneumoniae, Pseudomonas aeruginosa) with resistance to polymyxin class of antibiotics are a major threat.


Dr. Mark Walker of the University of Queensland in Brisbane and colleagues write in Science Translational Medicine," The emergence of polymyxin resistance in carbapenem (antibiotic class) -resistant and extended-spectrum beta-lactamase (ESBL)-producing bacteria is a critical threat to human health, and alternative treatment strategies are urgently required. "

PBT2, the experimental neurodegenerative drug when combined with polymyxin (a class of antibiotics) could disrupt and kill gram negative bacteria that can cause pneumonia, blood stream infections and meningitis (infection in the brain).

PBT2 has undergone the phase 2 clinical trials for neurodegenerative diseases to break polymyxin antibiotic resistance in four gram negative organisms including Klebsiella pneumoniae, Pseudomonas aeruginosa.

PBT2 can be taken orally and shows good absorption in the body. PBT2 is in phase 2 testing in patients with Huntington's and Alzheimer's disease.

Huntington's disease is a progressive brain disorder characterized by uncontrolled movements, emotional problems, loss of thinking ability.

It is given orally,250 mg once daily . This dose is well tolerated and safe for patients when given for periods up to 24 months.

In a previous study Dr Walker and colleagues found that antibiotic resistance in Gram positive bacteria could be overcome by repurposing PBT2 in combination with zinc. The latest study suggests that PBT2 has the ability to restore antibiotic sensitivity in polymyxin resistant, ESBL producing, carbapenem resistant gram negative human pathogens (bacteria resistant to even the higher classes of antibiotics).

In vitro PBT2 studies were done to resensitize Klebsiella pneumoniae, Escherichia coli, Acinetobacter baumannii, and Pseudomonas aeruginosa (these are the microorganisms resistant to most of the antibiotic classes) to "last-resort" polymyxin-class antibiotics including the next generation polymyxin derivative FADDI-287 (highest class of antibiotics available).

Even highly antibiotic resistant bacteria like K.pneumoniae showed succeptibility to the combination of PBT2 and polymyxin. This combination has successfully treated gram negative sepsis.

"The mechanism of action responsible for this effect appears to be mediated throughdysregulation of bacterial metal ion homeostasis," the researchers write.

Dr. Walker told," Demonstration of in vivo efficacy against Klebsiella sepsis in a mouse model (and) provides a new strategy for rescuing antibiotics that have lost efficacy due to antibiotic resistance development. We are looking towards undertaking a human trial of antibiotic in combination with PBT2 "

Source: Medindia

News A-Z
News Category
What's New on Medindia
Fermented Skin Care
Television Binge-Watching May Boost the Risk of Deadly Blood Clots
Western Diet may Augment the Risk of Autoimmune Diseases
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Drug Toxicity Shigellosis Signature Drug Toxicity MRSA - The Super Bug Drug Resistance - Antibiotic Resistance Drugs Banned in India Food Safety for Health Antibiotics Eye Infections Natural Antibiotics to Fight Bacterial Infections 

Recommended Reading
Beetroot Peptide can Help Treat Alzheimer’s, Hypertension and Diabetes
Peptide isolated from beetroot has shown promise in the treatment of hypertension, diabetes, ......
Want to be at a Lower Risk of Diabetes – Which is Better an Eggless or Egg Rich Diet?
Excessive consumption of egg can increase the risk of diabetes states a new research done at the ......
COVID 19 & Hypercoagulability: Increased Risk of Stroke, Heart Attack, DVT
COVID 19 patients with a history of heart attack, stroke and deep vein thrombosis should receive ......
Prolonged Androgen Deprivation Therapy Increases Risk of CV Death in Prostate Cancer Patients
Prolonged ADT therapy regimen and increased intensity of therapy is associated with increased ......
Antibiotics are among the most used and abused medications. This article explains some general featu...
Drug Resistance - Antibiotic Resistance
Drug resistance is often a problem in malaria, tuberculosis, HIV, sexually transmitted diseases and ...
Drug Toxicity
Drug toxicity is an adverse reaction of the body towards a drug that results as a side effect of a d...
Drugs Banned in India
Several drugs are either banned or withdrawn after introduction in the market....
Eye Infections
Eye infection is a common problem that often causes pain and discomfort to the eyes. Common symptoms...
MRSA - The Super Bug
MRSA infection is the most dreaded hospital or community acquired infection that can become ......
Natural Antibiotics to Fight Bacterial Infections
Fighting infections the natural way and preventing them is always more effective than consuming medi...
Shigellosis or Bacillary Dysentery is a common cause of gastro-enteritis worldwide and can cause blo...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2022

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
open close
I have read and I do accept terms of use - Telemedicine

Advantage Medindia: FREE subscription for 'Personalised Health & Wellness website with consultation' (Value Rs.300/-)