Researchers at the University of Oklahoma Health Sciences Center have discovered a new enzyme that seems to play a primary role in how cancer tumors expand and spread throughout the body.
A research team, led by Patrick McKee, first discovered the enzyme called sFAP in plasma.
Liver Cancer - Animation
Liver is the largest organ inside the human body. It performs 500 different functions and processes 720 liters of blood per day. The important functions of the liver, the development of liver cancer and it's symptoms are presented in this interactive.
Advertisement
After studying the biochemical makeup of the protein and identifying the gene that controlled its function, they began to search gene-sequencing databases worldwide to find what it was.
They didn't find the enzyme listed for blood, but got a match with a virtually identical protein known to cause cell growth in tissue, including in cancer.
![Prostate Cancer - Animation]( "Prostate Cancer - Animation")
With McKee's discovery that the protein also exists in blood, scientists have a new avenue to study the spread of cancer.
"One thing all cancer cells need as they grow is something that acts as scaffolding. They have to attach to the scaffolding to divide and migrate. This enzyme excavates space around a malignancy and helps create the scaffolding," said McKee, M.D., principle investigator on the project.
The main function of the original FAP protein that was known to exist in tissue is to accelerate tissue growth and expand cells during foetal development, the healing of severe wounds and during growth of selected cancers such as breast, lung, pancreatic and colon.
Other than in these situations, the original form of FAP is not normally expressed in tissues at all.
When it does appear, the protein helps activated fibroblasts, which growing cancer cells are able to recruit and stimulate to multiply within the malignancy itself.
This creates space and the framework on which cancer cells attach, divide and eventually spread.
The researchers believe if FAP could be inhibited, then cancer growth could be slowed or halted, which in combination with chemotherapy or radiation might offer the potential to actually cure the malignancy.
The study is published in recent issues of the journal Blood and the Journal of Thrombosis and Haemostasis.
Source: ANI
SRM
Advertisement
With McKee's discovery that the protein also exists in blood, scientists have a new avenue to study the spread of cancer.
"One thing all cancer cells need as they grow is something that acts as scaffolding. They have to attach to the scaffolding to divide and migrate. This enzyme excavates space around a malignancy and helps create the scaffolding," said McKee, M.D., principle investigator on the project.
The main function of the original FAP protein that was known to exist in tissue is to accelerate tissue growth and expand cells during foetal development, the healing of severe wounds and during growth of selected cancers such as breast, lung, pancreatic and colon.
Other than in these situations, the original form of FAP is not normally expressed in tissues at all.
When it does appear, the protein helps activated fibroblasts, which growing cancer cells are able to recruit and stimulate to multiply within the malignancy itself.
This creates space and the framework on which cancer cells attach, divide and eventually spread.
The researchers believe if FAP could be inhibited, then cancer growth could be slowed or halted, which in combination with chemotherapy or radiation might offer the potential to actually cure the malignancy.
The study is published in recent issues of the journal Blood and the Journal of Thrombosis and Haemostasis.
Source: ANI
SRM
Advertisement
Advertisement
|
Advertisement
Recommended Reading
Latest Cancer News
HR positive/HER2 negative breast cancer is the most common subtype of the disease and accounts for nearly 70% of breast cancer cases in the Unites States.
An antibody treatment helped shrink tumors in some patients with bile duct cancers.
Comprehending the association between the gut microbiome and polyp growth sheds insights into potential screenings and treatments.
The first large-scale, collaborative, open analysis of genomic data provides a cloud-based resource for researchers looking for more comprehensive data on pediatric brain tumors.
The mission of Axiom Space incorporated numerous experiments focusing on human stem cell aging, inflammation, and cancer within the laboratory situated in the low Earth orbit.