About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

New Enzyme That Plays Key Role In Cancer Growth Identified

by VR Sreeraman on December 6, 2008 at 2:43 PM
Font : A-A+

 New Enzyme That Plays Key Role In Cancer Growth Identified

Researchers at the University of Oklahoma Health Sciences Center have discovered a new enzyme that seems to play a primary role in how cancer tumors expand and spread throughout the body.

A research team, led by Patrick McKee, first discovered the enzyme called sFAP in plasma.

Advertisement

After studying the biochemical makeup of the protein and identifying the gene that controlled its function, they began to search gene-sequencing databases worldwide to find what it was.

They didn't find the enzyme listed for blood, but got a match with a virtually identical protein known to cause cell growth in tissue, including in cancer.
Advertisement

With McKee's discovery that the protein also exists in blood, scientists have a new avenue to study the spread of cancer.

"One thing all cancer cells need as they grow is something that acts as scaffolding. They have to attach to the scaffolding to divide and migrate. This enzyme excavates space around a malignancy and helps create the scaffolding," said McKee, M.D., principle investigator on the project.

The main function of the original FAP protein that was known to exist in tissue is to accelerate tissue growth and expand cells during foetal development, the healing of severe wounds and during growth of selected cancers such as breast, lung, pancreatic and colon.

Other than in these situations, the original form of FAP is not normally expressed in tissues at all.

When it does appear, the protein helps activated fibroblasts, which growing cancer cells are able to recruit and stimulate to multiply within the malignancy itself.

This creates space and the framework on which cancer cells attach, divide and eventually spread.

The researchers believe if FAP could be inhibited, then cancer growth could be slowed or halted, which in combination with chemotherapy or radiation might offer the potential to actually cure the malignancy.

The study is published in recent issues of the journal Blood and the Journal of Thrombosis and Haemostasis.

Source: ANI
SRM
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
Link between Dietary Intake of Plant-based Essential Fatty Acids and Death Risk
Aspirin may be Harmful When Used for Preventing 1st Heart Attack, Stroke
Pregnancy Complications Elevated Among Symptomatic COVID-19 Women
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Cancer and Homeopathy Cancer Facts Cancer Food Preservatives - How Safe Are They? Common Lifestyle Habits that Cause Diseases Health Benefits of Dandelion Plant Immune Checkpoint Inhibitors for Cancer Treatment Non-Communicable Diseases 

Recommended Reading
Liver Cancer - Animation
Liver is the largest organ inside the human body. It performs 500 different functions and processes ...
Prostate Cancer - Animation
Interactive section of Medindia gives details regarding Prostate Cancer...
Common Lifestyle Habits that Cause Diseases
Cigarette smoking, unhealthy diets, overuse of alcohol, and physical inactivity are some of the most...
Food Preservatives - How Safe Are They?
Food preservatives are basically antimicrobials or anti-oxidants that help preserve food by destroyi...
Health Benefits of Dandelion Plant
What is dandelion? Dandelion greens are nutrition powerhouses with a wide range of health benefits. ...
Immune Checkpoint Inhibitors for Cancer Treatment
Immune checkpoint inhibitors are promising drugs to treat a variety of cancers and the FDA has appro...
Non-Communicable Diseases
Non-Communicable Diseases (NCDs) are a group of chronic non-infectious diseases which include Cardio...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use