New Drug May Curb Female Infertility Following Cancer Treatment

Women who are treated for cancer with radiation or certain chemotherapy drugs are commonly rendered sterile in most of the cases. A team of scientists have identified a drug that may protect women from life-altering infertility that commonly follows cancer treatments. According to a 2006 study from Weill Cornell Medicine, nearly 40 percent of all female breast cancer survivors experience premature ovarian failure, in which they lose normal function of their ovaries and often become infertile. The current study identified a so-called checkpoint protein (CHK2) that becomes activated when oocytes are damaged by radiation. CHK2 functions in a pathway that eliminates oocytes with DNA damage, a natural function to protect against giving birth to offspring bearing new mutations. When the researchers irradiated mice lacking the CHK2 gene, the oocytes survived, eventually repaired the DNA damage, and the mice gave birth to healthy pups.

John Schimenti, the paper's senior author. Vera Rinaldi, a graduate student in Schimenti's lab, said, "It turns out there were pre-existing CHK2 inhibitor drugs that were developed, ironically enough, for cancer treatment, but they turned out not to be very useful for treating cancer. By giving mice the inhibitor drug, a small molecule, it essentially mimicked the knockout of the checkpoint gene." By inhibiting the checkpoint pathway, the oocytes were not killed by radiation and remained fertile, enabling birth of normal pups. Schimenti shared, "The one major concern is that even though these irradiated oocytes led to the birth of healthy mouse pups, it's conceivable that they harbor mutations that will become manifested in a generation or two, because we are circumventing an evolutionarily important mechanism of genetic quality control.

This needs to be investigated by genome sequencing." When doctors recognize the need for oocyte-damaging cancer treatments, women may have their oocytes or even ovarian tissue removed and frozen, but this practice delays treatment. Also, when women run out of oocytes, women's bodies naturally undergo menopause, as their hormonal systems shift. "That is a serious dilemma and emotional issue. When you layer a cancer diagnosis on top of the prospect of having permanent life-altering effects as a result of chemotherapy, and must face the urgent decision of delaying treatment to freeze oocytes at the risk of one's own life," noted Schimenti.

The study sets a precedent for co-administering this or related drugs and starting cancer therapy simultaneously, though such interventions would first require lengthy human trials. Schimenti concluded by saying, "While humans and mice have different physiologies, and there is much work to be done to determine safe and effective dosages for people, it is clear that we have the proof of principle for this approach." The study was published in Jounral Genetics.

Source-ANI