About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

New Drug for Malaria may Target the Mosquitoes Not the Parasite

by Chrisy Ngilneii on March 30, 2018 at 2:46 PM
Font : A-A+

New Drug for Malaria may Target the Mosquitoes Not the Parasite

A new anti-malaria drug has the potential to kill mosquitoes, unlike existing drugs that target the parasite. A research team at the Liverpool School of Tropical Medicine (LSTM) demonstrates the potential impact of ivermectin.

The team, working in partnership with the Kenya Medical Research Institute (KEMRI), the U.S. Centers for Disease Control and Prevention (CDC), and other colleagues from around the world, carried out a randomized controlled trial in western Kenya. The results of the study show that adding high doses of ivermectin, an endectocide class of drug, to the antimalarial dihydroartemisinin-piperaquine (DP) had a major and prolonged effect on mosquito mortality.

Advertisement


Dr. Menno Smit (LSTM) is first author on the paper. He said: "This is an entirely novel type of intervention which could be added to community-wide campaigns with antimalarial drugs, such as mass drug administration and seasonal malaria chemoprevention, to kill both mosquitoes and parasites. We worked with colleagues from Imperial College London, who used our results in a mathematical model, which predicts that the addition of high dose ivermectin increases the impact on malaria reduction by potentially as much as 61 percent."

Ivermectin is an antiparasitic drug and in lower doses is widely used in the treatment of other tropical diseases. It has safely been used in doses up to 10 times the standard dose. The team evaluated doses that were predicted to give drug levels that were 2 times and 4 times higher than the standard dose. They combined it with the malaria drug DP which is routinely used in mass drug administration in many malaria endemic countries. They found that three-day courses of ivermectin 300 and 600 mcg/kg/day were safe and routinely killed mosquitoes feeding on the blood of the treated individuals for at least 28 days post-treatment. These results suggest that ivermectin has the potential to become a novel tool for malaria control and elimination.
Advertisement

"This first evaluation of the impact of high dose ivermectin on mosquito mortality is highly encouraging and requires further evaluation in larger scale trials that target both malaria parasites and the mosquitoes, as the world pushes towards malaria elimination", explained LSTM's Professor Feiko ter Kuile, senior author of the paper. "The drug's impact on mosquito mortality, long effect-duration, and tolerability make it a promising new tool in malaria control. It has a different mode of action from other insecticides, meaning that it could also be effective against mosquitoes that rest and feed outdoors, as well as mosquitoes that are resistant to the standard insecticides used on bed nets and indoor spraying."

Preliminary results of the study were presented at a World Health Organization (WHO) evidence review group meeting, while UNITAID has issued a call for further research into the use of endectocide class drugs, of which ivermectin is currently the only one registered for human use, as new vector control tools in the fight against malaria and other mosquito borne disease.

The research is published in the journal The Lancet Infectious Diseases.

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
International Day of Persons with Disabilities 2021 - Fighting for Rights in the Post-COVID Era
Effect of Blood Group Type on COVID-19 Risk and Severity
Woman with Rare Spinal Cord Defect from Birth Sues Doctor
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Drug Toxicity Malaria-water Tapeworm Infections Malaria Mosquito Diseases Clinical Trials - Different Phases of the trial Trypanosomiasis Signature Drug Toxicity Drugs Banned in India Fever 

Recommended Reading
Malaria
Malaria is caused by a parasite that enters blood through the bite of an infected mosquito. It is .....
Malaria - Protection Strategies
Malaria is a dangerous disease with lethal consequences that requires protective measures for ......
Malaria - Waterborne
Encyclopedia section of medindia gives general information about About Malaria Causes...
Mosquito Diseases
Mosquito-borne diseases, like malaria, filaria, dengue, etc are common in places conducive of ......
Clinical Trials - Different Phases of the trial
Clinical trials serve as a vital component for improving the treatment of medical conditions as they...
Drug Toxicity
Drug toxicity is an adverse reaction of the body towards a drug that results as a side effect of a d...
Drugs Banned in India
Several drugs are either banned or withdrawn after introduction in the market....
Fever
Fever or Pyrexia is an elevation in normal body temperature. Causes of fever include infections, inj...
Tapeworm Infections
Tapeworms are a group of parasites that depend on humans for growth and cause intestinal infection i...
Trypanosomiasis
Sleeping sickness or Trypanosomiasis is a vector-borne parasitic disease which can trigger life-thre...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use