Effective treatments for sepsis remain elusive, despite numerous advances in treating infections and disease.
A new discovery published in the June 2013 issue of The FASEB Journal not only could help health care providers predict who is more and less likely to develop sepsis, but it also opens the doors to new therapies that actually address the root cause of the problem, rather than just managing the symptoms. This also has the potential to benefit patients suffering from influenza and other viral infections, as well as chronic inflammatory diseases such as periodontal disease, rheumatoid arthritis, inflammatory bowel disease and chronic obstructive pulmonary disease.
"Addressing infectious and inflammatory complications early and effectively in burn and trauma patients remains a significant unmet clinical need," said Daniel Irimia, M.D., Ph.D., a researcher involved in the work from the BioMEMS Resource Center and the Department of Surgery at Shriners Hospital for Children in Boston, MA. "This need is augmented by the difficulties of diagnosing infections early and the upsurge in frequency of multi-drug resistant bacteria."
"Reports of patients contracting deadly secondary infections while in the ICU continue to increase," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal, "but doctors have to find out what's wrong, and find it out quickly. This research should lead to faster diagnosis and better treatments for burns and sepsis. It's an important step on the way to new therapeutics."