New Discoveries For Alzheimer's Therapies Found

A recently discovered Alzheimer's-related mechanism, scienitsts suggest, could give rise to the development of new therapies against this disease.

The novelty lies in a new mechanism through which the amyloid peptide, the major pathogen in Alzheimer's disease, provokes neuronal death.

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Researchers from the University of the Basque Country (UPV/EHU) have found that this peptide activates some receptors that lead cells to overexcitation and subsequent death; when such receptors are blocked with specific drugs, neurons are protected from the peptide-related lethal effects.

This finding is particularly relevant for the development of new therapies slowing down Alzheimer's progression.

The research work was supervised by Dr. Carlos Matute, Director of Neurotek research centre and Head of the Neurobiology Laboratory of the Neurosciences Department at the University of the Basque Country (UPV/EHU).

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Scientists have found that the protein that forms plaques in the brain in Alzheimer's disease also accumulates in the eyes of people with Down syndrome.

The research team led by Dr. Matute deals with the molecular and cell fundamentals of neurodegenerative diseases such as Alzheimer's or multiple sclerosis.

In particular, it focuses on the mechanism leading to cell death in the nervous system by using different tests based on cell cultures,

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experimental animals, human brains coming from demised people suffering these diseases and living patients' samples.

This team, which has already released many patents, also searches for markers supporting early diagnosis of these diseases.

Two New Genes Behind Alzheimer's Identified
US and European researchers have identified two new genes that may play a role in the development of Alzheimer's disease and could help unravel new treatments, a study published Tuesday said.

The study was recently published in the Cell Calcium journal.

Source-ANI
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