About Careers MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

New Compound Identified To Cure Cataracts With Eye Drops

by Bidita Debnath on November 7, 2015 at 1:30 AM
Font : A-A+

 New Compound Identified To Cure Cataracts With Eye Drops

Cataracts are primarily a disease of aging. A team of researchers has identified a chemical that could potentially be used in eye drops to reverse cataracts, the leading cause of blindness.

UC San Francisco (UCSF), the University of Michigan (U-M), and Washington University in St. Louis (WUSTL) researchers' newly identified compound is the first that is soluble enough to potentially form the basis of a practical eye-drop medication for cataracts.

Advertisement


As is seen in neurodegenerative conditions such as Alzheimer's disease and Parkinson's disease, a hallmark of the condition is the misfolding and clumping together of crucial proteins. In the case of cataracts, the affected proteins are known as crystallins. Crystallins are the major component of fiber cells, which form the eyes' lenses, and the unique properties of these cells make them particularly susceptible to damage, said co-senior author Jason Gestwicki.

The team next tested compound 29 in an eye-drop formulation in mice carrying mutations that make them predisposed to cataracts. In experiments conducted with Usha P. Andley, they found that the drops partially restored transparency to mouse lenses affected by cataracts, as measured by a slit-lamp test of the sort used by ophthalmologists to measure cataracts in humans.
Advertisement

Similar results were seen when compound 29 eye drops were applied in mice that naturally developed age-related cataracts and also when the compound was applied to human lens tissue affected by cataracts that had been removed during surgery.

Gestwicki cautions that slit-lamp measures of lens transparency used in the research are not a direct measure of visual acuity and that only clinical trials in humans can establish the value of compound 29 as a cataract treatment. The study is reported in Science.

Source: ANI
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Diet and Oral Health: The Sugary Connection May Become Sour
World AIDS Day 2022 - Equalize!
Test Your Knowledge on Sugar Intake and Oral Health
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Cataract Cataract in Detail Eye Vision LASIK Surgery Facts Allergy Eye Drops Routine Eye Examination Quiz On Eye Donation Floppy Iris Syndrome Eyelid Bump 

Most Popular on Medindia

Indian Medical Journals Diaphragmatic Hernia Drug - Food Interactions Blood Donation - Recipients Blood Pressure Calculator Iron Intake Calculator Loram (2 mg) (Lorazepam) Sinopril (2mg) (Lacidipine) Drug Side Effects Calculator Accident and Trauma Care
This site uses cookies to deliver our services.By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use  Ok, Got it. Close
×

New Compound Identified To Cure Cataracts With Eye Drops Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests