A protein called as kinase suppressor of Ras (KSR) could be used to develop new cancer therapies, says a new research from The Tisch Cancer Institute at the Icahn School of Medicine at Mount Sinai. KSR is a pseudoenzyme that plays a critical role in the transmission of signals in the cell determining whether cells grow, divide, or die. The study shows that KSR could have important therapeutic implications, potentially improving in many aggressing cancers such as lung and pancreatic cancer.
Ras is the most frequently mutated human cancer gene (oncogene), yet despite recent breakthroughs, therapeutic options to target Ras-dependent cancers remain limited. Previous studies had supported the possibility of targeting oncogenic forms of Ras via KSR, but no pharmacological approaches had been reported until now.
"New drug targets for Ras-dependent cancers have long been sought," said Arvin Dar, PhD, Assistant Professor of Oncological Sciences and Pharmacological Sciences at The Tisch Cancer Institute at the Icahn School of Medicine at Mount Sinai and lead researcher on the study. "We used data on known genetic variants in KSR that suppress mutant Ras signaling to guide the development of novel compounds. In this way our study took a very different approach as we have used chemistry to mimic genetic mechanisms that are able to block the development of Ras-dependent cancers."
The findings are published in the journal Nature.