About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

New Class of Compounds can Lead to More Effective Drugs Against Flu

by Kathy Jones on February 23, 2013 at 6:47 PM
Font : A-A+

 New Class of Compounds can Lead to More Effective Drugs Against Flu

Researchers led by Masahiro Niikura and Nicole Bance at Simon Fraser University have developed a new class of molecular compounds that can be used to develop more effective drugs which flu virus strains cannot easily adapt to.

Their study reveals how to use their newly-discovered compounds to interrupt the enzyme neuraminidase's facilitation of the flu's spread, reports the journal Science Express.

Advertisement

Tamiflu and another flu drug, Relenza, focus on interrupting neuraminidase's ability to help flu virus detach from an infected cell's surface by digesting sialic acid, a sugar on the cell surface.

The virus uses the same sugar to stick to the cell while invading it. Once attached, influenza can invade the cell and replicate.

This is where the newly-discovered compounds come to the still-healthy cells' rescue. They clog up neuraminidase, stopping the enzyme from dissolving the sialic acid, which prevents the virus from escaping the infected cell and spreading, according to a Simon Fraser statement.
Advertisement

The new compounds are also more effective because they are water-soluble. "They reach the patient's throat where the flu virus is replicating after being taken orally," says Niikura, associate professor.

"Influenza develops resistance to Replenza less frequently, but it's not the drug of choice like Tamiflu because it's not water-soluble and has to be taken as a nasal spray.

"Our new compounds are structurally more similar to sialic acid than Tamiflu. We expect this closer match will make it much more difficult for influenza to adapt to new drugs," adds Niikura.

Ultimately, the new compounds will buy scientists more time to develop new vaccines for emerging strains of influenza that are resistant to existing vaccines.

Source: IANS
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
Turmeric: Magic Ingredient to Keep you Healthy in Winter
Top 7 Benefits of Good Oral Hygiene
Healthy and Safer Thanksgiving 2021
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Drug Toxicity Swine Flu Drugs Banned in India 

Recommended Reading
Swine Flu
Swine flu, a type of influenza caused by a new strain of the H1N1 Type A influenza virus has ......
Bird Flu
Bird flu (avian influenza/avian flu) is a disease caused by an influenza virus (H5N1) that ......
Hepatitis B
Hepatitis B is inflammation of the liver due to infection with the hepatitis B virus....
Drug Toxicity
Drug toxicity is an adverse reaction of the body towards a drug that results as a side effect of a d...
Drugs Banned in India
Several drugs are either banned or withdrawn after introduction in the market....

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use