A new cell therapy for chronic inflammatory conditions such as Crohn's disease, where the patient's own blood cells are used to produce a type of cell - Type 1 T regulatory lymphocyte, has been successful in the first phase of clinical trial.
Speaking at the UK National Stem Cell Network annual science meeting later today (30 March), Professor Miguel Forte will describe research into a new cell therapy for chronic inflammatory conditions such as Crohn's disease. Patient's own blood cells are used to produce a type of cell - Type 1 T regulatory lymphocyte - that can reduce the extent of the disease.
Professor Forte said "T regulatory lymphocytes are amazing cells - they secrete proteins - cytokines - that dampen down the over active immune response that causes the terrible symptoms of chronic inflammatory diseases such as Crohn's. We know that treatments based on these cells can work but the challenge is to develop them in the clinic so as to maximise the benefits and minimise the risk. We must show that these cells are well tolerated and do a good job to treat the disease."
Cell therapy approaches, like this one and also MSCs, aim at using living cells as innovative new treatments to address unmet medical needs.
Professor Forte continued "It's still early days but the preliminary results are really good. The treatment didn't make the patients ill in any way and there is an early indication that their Crohn's disease has improved. The next step will be to do what we call a "phase 2b" clinical trial to find out if the treatment definitely works, what types of chronic inflammatory disease it works for, more about any potential side effects and how to manage them, and to confirm our results on the best dose used."