About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

New Blood Test Reduces Diagnosis Time for Candidemia, a Deadly Yeast Infection

by Colleen Fleiss on February 8, 2018 at 11:57 PM
Font : A-A+

New Blood Test Reduces Diagnosis Time for Candidemia, a Deadly Yeast Infection

A novel blood test developed by UPMC research team was found to perform better than traditional blood cultures at detecting candidemia, a type of fungal yeast infection.

The T2Candida Panel is the first diagnostic test for candidemia - a type of bloodstream infection caused by Candida yeast - that has been cleared by the U.S. Food and Drug Administration and doesn't require culturing a blood sample from the patient to see what grows. The results of the trial, named DIRECT2, are reported today in the journal Clinical Infectious Diseases. The trial was funded by T2 Biosystems, the company that makes the panel, which is used by UPMC.

Advertisement


"There are many advantages to quickly diagnosing the specific type of infection a patient has," said lead author Cornelius J. Clancy, M.D., associate professor of medicine in the University of Pittsburgh's Division of Infectious Diseases, and director of the mycology program. "With an accurate diagnosis, we can start the patient on the correct medication for the type of infection he or she has, which will hopefully allow us to stop the infection before it spreads, but also keep us from giving the patient a drug that won't work and potentially contributing to drug resistance. For candidemia, we know that the shorter the time to administering an active antifungal medication to a patient, the higher the survival rate. "

Candidemia is among the four most common bloodstream infections in U.S. hospitals, and Candida are the third most common cause of infections in intensive care units. The mortality rate among patients with candidemia is 40 percent. Blood cultures fail to detect yeast in approximately 50 percent of Candida infections, and typically take two to three days for positive results to be apparent.
Advertisement

The T2Candida Panel involves putting a small vial of blood from the patient into a desktop machine that uses magnetic resonance to scan the blood for the five most common Candida species. Positive or negative results are available within five hours.

From 14 U.S. hospitals, including UPMC, Clancy's team enrolled 152 patients who had been diagnosed with candidemia through a blood culture. On average, it took nearly two days for the culture to identify that the patient had candidemia, and another day-and-a-half to specify which strain of Candida.

In the trial, the T2Candida test was positive in 89 percent of patients at the time of a positive blood culture for Candida. The T2Candida Panel was significantly more likely to be positive than blood cultures in patients with recent candidemia, in particular those patients who were being treated with antifungal drugs.

While the T2Candida Panel performed well in the trial, Clancy says there were limitations, including the fact that the study didn't assess whether T2Candida shortens time to starting antifungal treatment or improves patient outcomes.

"Our trial demonstrates that the T2Candida Panel is an important advance in the diagnosis of candidemia," said Clancy. "The next steps should be evaluating it in direct clinical practice and determining if its use truly speeds up antifungal treatment, cuts unnecessary drug prescribing, results in better patient outcomes and is cost-effective, and identifies large numbers of candidemia cases that are currently not detected by blood cultures."

T2 Biosystems provided assistance with the study design and compiled data from each institution in a central database. The study authors performed data and statistical analyses and prepared the manuscript without assistance from the company.

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
Goji Berries May Protect Against Age-Related Vision Loss
Tapping — A Proven Self-Applied Stress Intervention
Black Pepper as Preventive Measure Against Omicron
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Thalassemia Undescended Testicles Varicocele Amyotrophic Lateral Sclerosis (ALS) Quiz on Depression Candida Diet Testicle Pain - Symptom Evaluation Blood in Stools - Symptom Evaluation Bombay Blood Group Histoplasmosis 

Recommended Reading
Yeast Infections
We only know yeast as the fermenting organism for bread making, however it can cause also ......
Quiz on Skin Infections
Skin infections are caused by bacteria, viruses, fungi or parasites. Factors such as injuries, poor ...
CDC Issues Multi-drug Resistant Yeast Infection Warning to US Healthcare Facilities
Since 2009, the pathogen has been found in nine countries on four continents, including one ......
Vaginal Douching Ups The Risk Of Ovarian Cancer
Vaginal douching could be a marker for ovarian cancer...
Amyotrophic Lateral Sclerosis (ALS)
Find out more about the degenerative disease- Amyotrophic lateral sclerosis....
Blood in Stools - Symptom Evaluation
Blood in stools results from bleeding that arises from any part of the digestive tract. Causes of bl...
Bombay Blood Group
Bombay blood group is a rare blood type in which the people have an H antigen deficiency. They can r...
Candida Diet
It is possible to reverse Candida infection through a strictly followed Candida diet plan. Candida d...
Histoplasmosis
Histoplasmosis is a fungal infection caused by breathing spores of the fungus from bird or bat dropp...
Testicle Pain - Symptom Evaluation
A sudden, severe pain in the testis may be due to testicular torsion. Testicles inside the scrotum a...
Thalassemia
Thalassemia is an inherited blood disorder passed on through parental genes causing the body to prod...
Undescended Testicles
An undescended testicle / testis is one that has not descended into the scrotal sac before birth. It...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2022

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
open close
CONSULT A DOCTOR
I have read and I do accept terms of use - Telemedicine

Advantage Medindia: FREE subscription for 'Personalised Health & Wellness website with consultation' (Value Rs.300/-)