About My Health Careers Internship MedBlogs Contact us
Medindia
LOGIN REGISTER
Advertisement

New Biomarker Helps Identify Men With Prostate Cancer at Increased Risk of Tumor Metastasis

by Colleen Fleiss on May 10, 2019 at 10:20 AM
Font : A-A+

New Biomarker Helps Identify Men With Prostate Cancer at Increased Risk of Tumor Metastasis

Levels and distribution of syntaphilin within tumors may differentiate the subset of patients with prostate cancer who require more aggressive management and treatment, according to a new study in The American Journal of Pathology.

For about 90 percent of men with prostate cancer, the cancer remains localized to the primary site, resulting in a five-year survival rate of almost 100 percent. Unfortunately, the remaining 10 percent of patients develop locally invasive and metastatic disease, which increases the severity of the disease and likelihood of death and limits treatment options. These patients may require more rigorous testing, surveillance, and treatment.

Advertisement


"Predicting aggressive behavior in prostate cancer is an entirely unmet and urgent need. There are currently no tissue-based biomarkers to help clinicians reliably identify the subset of prostate cancer patients who will progress to life-threatening, disseminated disease and who would, therefore, benefit from systemic therapies before or following prostatectomy. If our findings are supported by larger studies, SNPH measurement in tumors could be developed into a predictive biomarker," explained Marie E. Robert, MD, of the Department of Pathology, Yale School of Medicine, New Haven, CT, USA.

In this study, investigators found that SNPH, a key determinant of the balance between tumor cell proliferation and tumor cell invasion, is abundantly expressed in prostate cancer, where it exhibits high expression at the invasive tumor edge compared to the central tumor bulk, correlating with greater cell proliferation at the tumor edge location. They also found that SNPH expression increases with increasing Gleason pattern. Of potential vital clinical relevance, low central tumor expression correlated with an increased risk of metastasis in a group of patients undergoing radical prostatectomy.
Advertisement

The investigators analyzed tissue specimens from 89 men with prostate adenocarcinoma who had undergone removal of the prostate. They found that SNPH manifests a unique, biphasic spatial distribution in prostate tumors, meaning that in 96 percent of the prostate cancer tumors analyzed, SNPH levels were elevated at the outer invasive edge where it correlates with increased tumor cell proliferation, but decreased within the central tumor core. This differential was more pronounced in more advanced tumors.

Importantly, central tumor SNPH measures (H scores) were significantly lower in 16 patients with metastases compared to patients without metastases, whereas SNPH scores at the invasive edges were not different in patients with or without metastases. Most of the metastases also expressed SNPH strongly. The researchers suggest that SNPH acts as a negative regulator of mitochondrial activity and that its down-regulation in the central portions of primary prostate cancer is associated with an increased risk of metastatic disease.

"Our results also reaffirm a critical, emerging role of mitochondrial biology in influencing tumor behavior," Dr. Robert noted.

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
Emotional Healing
Psychosis Risk Related to Cat Parasite
Sedentary Behavior Precipitates Night-Time Hot Flashes
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Prostate Cancer Cancer and Homeopathy Trans-Urethral Resection of the Prostate Prostate Cancer Facts Cancer Facts Cancer Tattoos A Body Art Tumor Markers For Cancer Diagnosis and Prognosis Prostate Cancer: Treatment Options Prostate Specific Antigen [PSA] 

Recommended Reading
Brachytherapy for Prostate Cancer
Learn about two different types of brachytherapy used for treating prostate cancer. Get information ...
Decipher Test for Prostate Cancer
Decipher test a genomic test for prostate cancer that determines the aggressiveness of the cancer .....
Quiz on Prostate Cancer
Prostate cancer is fast gaining as a common cancer form among men; more threatening since its ......
Benign Prostatic Hyperplasia Assessment | Prostate Self Assessment Calculator
Benign Prostatic Hyperplasia Assessment or Prostate Self Assessment Calculator assesses the ......
Prostate Cancer
This cancer affects men over the age of 50 years and screening with rectal examination and PSA can h...
Prostate Cancer: Treatment Options
Treatment options of prostate cancer includes waiting, surgery, radiation, hormone therapy, chemothe...
Prostate Specific Antigen [PSA]
PSA blood test is specific to prostate gland but not necessarily a cancer specific test but is commo...
Tattoos A Body Art
Tattoos are a rage among college students who sport it for the ‘cool dude’ or ‘cool babe’ look...
Tumor Markers For Cancer Diagnosis and Prognosis
An ideal tumor marker for a cancer should be specific to that cancer and not generate false positive...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use