About Careers MedBlog Contact us

New Bio-marker for Detecting Colorectal Cancer Metastases

by Dr. Trupti Shirole on January 31, 2015 at 1:57 AM
Font : A-A+

 New Bio-marker for Detecting Colorectal Cancer Metastases

A unique metastasis-specific microRNA signature in primary colorectal cancers that could predict prognosis and distant metastasis in colorectal cancer has been developed at the Center for Gastrointestinal Cancer Research and the Center for Epigenetics, Cancer Prevention and Cancer Genomics at Baylor Research Institute.

Colorectal cancer is the second-leading cause of cancer-related death worldwide. Distant metastasis is the major cause of mortality and serious morbidity in cancer patients. Researchers originally identified the need for specific biomarkers that could predict outcomes of colorectal cancer distant metastasis in order for physicians to suggest more effective therapies.


Investigator Dr. Ajay goel said, "The challenge is when it comes to colon cancer, it's still a very common cancer. Fifty percent of people in the U.S. aren't following recommended guidelines for colorectal cancer screening. The good news is this disease doesn't happen overnight."

The findings of the study would help determine which colorectal cancer patients have a high risk of developing distant metastases, of which liver metastasis is the most common manifestation. With these results, oncologists can better predict which patients need more extensive treatment to avoid over treating or under treating colorectal cancer in patients.

Dr. Goel said, "We've been doing this a long time. The fundamental basis is trying to understand who has a risk of developing colorectal cancer, and then understanding which patients have higher risks of their cancer spreading to lymph nodes and other distant organs."

A third phase of the study is currently underway. Researchers will take the results from the blood test and metastasis-specific microRNA study to develop markers for identifying different stages of colorectal cancer, and which drugs best treat those stages. The results could help establish individualized treatment and ultimately, start treating the right type of cancer with the right type of drug.

The study is published in the 'Journal of the National Cancer Institute'.

Source: Medindia


Recommended Reading

Latest Cancer News

Could TKI Cancer Drugs Lead to Inflammatory Side Effects?
The mechanism by which the kinases cause inflammation has been discovered by scientists.
Are Biomarkers the Key to Identifying Early Pancreatic Risk?
Pancreatic cancer cases are on the rise. The biomarker approach could reduce the chance of developing pancreatic cancer.
How Does New Drugs Work Together to Reduce Lung Tumors?
New combination of medications trametinib and entinostat were found to decrease lung cancer in mice.
New Combination Therapy Proves Effective Against Prostate Cancer
Combination treatment with TALZENNA and XTANDI was found to benefit prostate cancer patients, revealed study.
Can Vitamin A Rich Diet Help Reduce Pancreatitis Risk
In leukemia patients, reduced amounts of dietary vitamin A is associated with a higher risk and severity of pancreatitis.
View All
This site uses cookies to deliver our services.By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use  Ok, Got it. Close

New Bio-marker for Detecting Colorectal Cancer Metastases Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests