Common Chemotherapy Has Negligible Cardiac Toxicity in Patients With BRCA1/2 Mutations
Use of anthracycline-based chemotherapy has negligible cardiac toxicity in women whose tumors have BRCA1/2 mutations -- despite preclinical evidence that such treatment can damage the heart.
Use of anthracycline-based chemotherapy has negligible cardiac toxicity in women whose tumors have BRCA1/2 mutations -- despite preclinical evidence that such treatment can damage the heart.
‘The new technique identifies chemotherapy-resistant tumors and tumor cells prior to treatment and improve therapeutic outcomes in acute myeloid leukemia.’
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Studying the characteristics of these cells could help researchers understand and develop better approaches to target chemotherapy-resistant cancers. This month in the JCI, Anthony Letai and colleagues at the Dana-Farber Cancer Institute developed an assay to determine how variability within a population of tumor cells can predict responses to chemotherapy in acute myeloid leukemia patients. The assay, which was performed on single cells, measured each cell's sensitivity to mitochondrial apoptosis, a type of cell death that is induced by many existing chemotherapies. They determined that the least sensitive cells in a tumor could predict how successfully a patient responded to chemotherapy.
Developing the ability to identify chemotherapy-resistant tumors and tumor cells prior to treatment may lead to clinical insights that improve therapeutic outcomes in acute myeloid leukemia and other cancers.
Identification Of Culprit Behind Chemotherapy Resistance in Cancer
A protein that enables cancer cells to grow, invade tissues and eventually resist chemotherapy and has lethal consequences for patients was found by researchers.
A protein that enables cancer cells to grow, invade tissues and eventually resist chemotherapy and has lethal consequences for patients was found by researchers.
Chemotherapy Drug Etoposide Used During Pregnancy Affects Future Fertility Of Female Offspring
Pregnant women with cancer, who use etoposide, may give birth to female babies who are likely to undergo an early menopause.
Pregnant women with cancer, who use etoposide, may give birth to female babies who are likely to undergo an early menopause.
Cancer Doctor in the US Held Guilty For Prescribing 2,770 Unnecessary Chemotherapy Drugs
There were abnormalities in drug combinations, dosage levels, chemotherapy periods and outpatient treatments for people who should have treated as inpatients.
There were abnormalities in drug combinations, dosage levels, chemotherapy periods and outpatient treatments for people who should have treated as inpatients.
