Asiaticoside has been shown to attenuate in vitro neuronal damage caused by exposure to β-amyloid, in the central nervous system.
However, its potential neuroprotective properties in glutamate-induced excitotoxicity have not been fully studied. Researchers from Fourth Military Medical University of Chinese PLA, China reported that pretreatment with Asiaticoside decreased neuronal cell loss in a concentration-dependent manner and restored changes in expression of apoptotic-related proteins Bcl-2 and Bax.
Selective Verbal Memory Impairment Due to Left Fornical Crus Injury After Intraventricular Hemorrhage
A part of the Papez circuit, the fornix, transfers information of episodic memory between the medial temporal lobe and the medial diencephalon.
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Asiaticoside pretreatment also attenuated the upregulation of NR2B expression, a subunit of N-methyl-D-aspartate receptors, but did not affect expression of NR2A subunits. Additionally, in cultured neurons, Asiaticoside significantly inhibited Ca2+ influx induced by N-methyl-D-aspartate. Their results provide a new insight into the neuroprotective effects of Asiaticoside. The relevant study has been published in the Neural Regeneration Research (Vol. 9, No. 13, 2014).
Source: Eurekalert
Study Shows Role of Notch-1 Signaling Pathway in PC12 Cell Apoptosis
Notch-1 expression is increased in the hippocampus of Alzheimer's disease patients, suggest recent studies.
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 Scientists Uncover New Clues to Repair an Injured Spinal CordDogs, frogs, whales, snails can all do it, but humans and primates can't regrow nerves after an injury. Many animals have this ability, but humans don't. | Advertisement
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Analysis of the Optic Radiation in the Normal Human Brain
The optic radiation is a dense fiber tract which emerges from the lateral geniculate nucleus and it continues to the occipital visual cortex.
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