About Careers MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

Neuroprotective Effects of Asiaticoside in the Central Nervous System

by Bidita Debnath on August 12, 2014 at 11:34 PM
Font : A-A+

 Neuroprotective Effects of Asiaticoside in the Central Nervous System

Asiaticoside has been shown to attenuate in vitro neuronal damage caused by exposure to β-amyloid, in the central nervous system.

However, its potential neuroprotective properties in glutamate-induced excitotoxicity have not been fully studied. Researchers from Fourth Military Medical University of Chinese PLA, China reported that pretreatment with Asiaticoside decreased neuronal cell loss in a concentration-dependent manner and restored changes in expression of apoptotic-related proteins Bcl-2 and Bax.

Advertisement

Asiaticoside pretreatment also attenuated the upregulation of NR2B expression, a subunit of N-methyl-D-aspartate receptors, but did not affect expression of NR2A subunits. Additionally, in cultured neurons, Asiaticoside significantly inhibited Ca2+ influx induced by N-methyl-D-aspartate. Their results provide a new insight into the neuroprotective effects of Asiaticoside. The relevant study has been published in the Neural Regeneration Research (Vol. 9, No. 13, 2014).

Source: Eurekalert
Advertisement

Advertisement
Advertisement

Recommended Reading

Latest Research News

What Are the Effects of Smoking on Quality of Life?
Tobacco smoke contains toxic chemicals which damage lungs, weaken the immune system and cause tuberculosis.
 Brain Shape Controls Our Thoughts, Feelings, and Behaviour
Identifying an unappreciated relationship between brain shape and activity overturns the century-old paradigm emphasizing the importance of complex brain connectivity.
Eight Threats to Black Adult's Longevity
Decoding the eight factors affecting Black adults' life expectancy.
Beyond the Campus: Contrasting Realities Revealed!
Sobering truth about foot travel in the United States emerges from international statistics, highlighting the prevalence of walking on the Blacksburg campus.
Astounding Link Between Darwin's Theory and Synaptic Plasticity — Discovered!
Unveiling a hidden mechanism, proteins within brain cells exhibit newfound abilities at synapses, reinforcing Darwin's theory of adaptation and diversity in the natural world.
View All
This site uses cookies to deliver our services.By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use  Ok, Got it. Close
×

Neuroprotective Effects of Asiaticoside in the Central Nervous System Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests