About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Neuronal Activity Induces Tau Release from Healthy Neurons: Researchers

by Rukmani Krishna on February 19, 2013 at 10:08 PM
Font : A-A+

 Neuronal Activity Induces Tau Release from Healthy Neurons: Researchers

Neuronal activity can stimulate tau release from healthy neurons in the absence of cell death discovers researchers from King's College London. Treatment of neurons with known biological signaling molecules increases the release of tau into the culture medi-um. The release of tau from cortical neurons is therefore a physiological process that can be regulated by neuronal activity. The results were published by Diane Hanger and her colleagues in EMBO reports.

Tau proteins stabilize microtubules, the long threads of polymers that help to maintain the structure of the cell. However, in Alzheimer's disease or certain types of dementia, tau accumulates in neurons or glial cells, where it contributes to neurodegeneration.In addition to intracellular aggregation, recent experiments have shown that tau is released from neuronal cells and taken up by neighboring cells, which allows the spread of aggregated tau across the brain. This release could occur passive-ly from dying neuronal cells, though some evidence suggests it might take place before neuronal cell death and neurodegeneration.

Advertisement

The new findings indicate that tau release is an active process in healthy neurons and this could be altered in diseased brains."Our findings suggest that altered tau release is likely to occur in response to changes in neuronal excitability in the Alzheimer's brain. Secreted tau could therefore be involved in the propagation of tau pathology in tauopathies, a group of neurodegenerative diseases associated with the accumulation of tau proteins in the brain," commented Diane Hanger, Reader in the Department of Neuroscience at King's College London.

In these experiments, Amy Pooler, the lead au-thor, revealed that molecules such as potassium chloride, glutamate or an AM-PA receptor agonist could release tau from cortical neurons in an active physio-logical process that is, at least partially, dependent on pre-synaptic vesicle se-cretion.The new findings by the scientists indicate that tau has previously unknown roles in biological signaling between cells, in addition to its well-established role in stabilizing microtubules. "We believe that targeting the release of tau could be explored as a new thera-peutic approach for the treatment of Alzheimer's disease and related tauopa-thies," said Hanger. Additional studies are needed in model organisms to test this hypothesis further.

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
Goji Berries May Protect Against Age-Related Vision Loss
Tapping — A Proven Self-Applied Stress Intervention
Black Pepper as Preventive Measure Against Omicron
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Healthy Gifting Ideas for Diwali 

Recommended Reading
Nasal Spray Aids Early Detection of Alzheimer
The nasal spray can show whether the damaging tau protein that kills brain cells, is present in the ...
Brain Sugar Levels Could Help Combat Alzheimer's Disease
Maintaining the brain protein's sugar levels can help slow or prevent the development of ......
Early Detection of Alzheimer's Disease
Alzheimer's disease is likely detectable 20 years before the onset of symptoms, reveals study....
Hsp27 Protein Fetches New Assurance Against Alzheimer's Disease
In a recent work scientists pointed out the effective regulation of the chaperone protein Hsp27....
Healthy Gifting Ideas for Diwali
Diwali, the festival of lights is round the corner. Take a fat free route when it comes to gifting t...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2022

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
open close
CONSULT A DOCTOR
I have read and I do accept terms of use - Telemedicine

Advantage Medindia: FREE subscription for 'Personalised Health & Wellness website with consultation' (Value Rs.300/-)