About Careers Internship MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

‘Network Drugs’ to Treat Resistant Prostate Cancer

by Shirley Johanna on May 2, 2016 at 12:26 PM
Font : A-A+

Men with aggressive prostate cancer may benefit from a new class of drug when the conventional treatments fail, said researchers from the Institute of Cancer Research.

The researchers found that the drugs, called Hsp90 inhibitors, target and inactivated a mechanism commonly used by prostate cancer cells to evade the effects of standard treatment.

Advertisement

‘Network Drugs’ to Treat Resistant Prostate Cancer
‘Network Drugs’ to Treat Resistant Prostate Cancer

The research team said that Hsp90 inhibitors are particularly promising for treating drug-resistant cancers.

Prostate cancer affects men over the age of 50. Cancer can sometimes be treated successfully with hormone treatments, which target androgen receptors linked to the growth of male hormones called androgens.
Advertisement

But some prostate cancers create an abnormal form of androgen receptor which is not linked to the growth of hormones and therefore does not respond to standard hormone treatment. This form of resistance in prostate cancer leads to aggressive, difficult-to-treat cancers.

The current research, published in the journal Cancer Research, found that a new class of drugs reduced production of both receptors.

Professor Paul Workman, study author and chief executive of the Institute of Cancer Research, said, "It was an exciting discovery.We call Hsp90 inhibitors 'network drugs' because they tackle several of the signals that are hijacked in cancer all at once, across a network rather than just a single signaling pathway."

"These drugs can hit cancer harder than those targeting only one protein, and look promising for preventing or overcoming drug resistance."

The next step will be to test the Hsp90 inhibitors in clinical trials on patients with aggressive, drug-resistant prostate cancer, said Prof Workman.

Prof Johann de Bono, a professor of experimental cancer medicine at the Institute of Cancer Research, said, "These drugs are already in clinical trials for several types of cancer, and I am excited that our work suggests they could also benefit men with prostate cancer who have otherwise run out of treatment options."

Source: Medindia
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Quiz on Low-Calorie Diet for Diabetes
World Heart Day in 2022- Use Heart for Every Heart
Anemia among Indian Women and Children Remains a Cause of Concern- National Family Health Survey-5
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Prostate Cancer Cancer and Homeopathy Trans-Urethral Resection of the Prostate Prostate Cancer Facts Cancer Facts Cancer Tattoos A Body Art Prostate Cancer: Treatment Options Prostate Specific Antigen [PSA] Nutrition All Men Need 

Most Popular on Medindia

Sanatogen Drug Interaction Checker Noscaphene (Noscapine) How to Reduce School Bag Weight - Simple Tips Drug Side Effects Calculator Diaphragmatic Hernia Find a Hospital Drug - Food Interactions Nutam (400mg) (Piracetam) Pregnancy Confirmation Calculator
This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
×

‘Network Drugs’ to Treat Resistant Prostate Cancer Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests