Needle-free vaccination that can stimulate the immune response of the human skin is now possible, revealed a research published in Experimental Dermatology.
Vaccination is an effective method of stimulating the human body's immune system to fight against various pathogens such as bacteria and viruses. There is a need for safe, easy-to-use and inexpensive tools for vaccine administration. The immune system of the skin is a promising target as the skin lies directly in front of us.
Vaccination for Children
Vaccines are biological products that impart immunity to the recipient. Vaccines may be live attenuated, killed or toxoids.
Advertisement
Researcher Annika Vogt said, "For 10 years, we have been working together on how to use the skin immune system to develop a new, non-invasive vaccination method and in this study, we show how a painless method helps such vaccines cross the skin. The method wakes up skin immune cells so that they are ready to catch the vaccine and generate an immune response."
To make this discovery, the researchers treated natural skin samples with a novel method called cyanoacrylate skin surface stripping (CSSS). They then applied 200 nm particles to the skin surface and used microscopy to compare the penetration of the particles. The particle size reflects the size of viruses and engineered particulate vaccines. They found that the CSSS method enhanced the penetration of the particles to the deeper skin layers, especially to the hair follicles, and activated skin dendritic cells which are key players in the orchestration of the skin immune system.
![Vaccination During Pregnancy]( "Vaccination During Pregnancy")
Healthcare providers should counsel pregnant women about the benefits of receiving the recommended vaccines during pregnancy and also the potential risks it may pose to the developing fetus.
Results of this novel approach strongly suggest that the combination of an adequate skin treatment with a vaccine specifically designed to target skin immune cells could become a powerful tool for mass vaccination. The findings should be further investigated in clinical trials. Vogt concluded, "If we learn how to better reach and communicate with skin immune cells from the outside, we would be able to develop new tools for the treatment of allergies, inflammatory skin diseases or skin cancer."
Source: Medindia
Vaccination During Pregnancy
Healthcare providers should counsel pregnant women about the benefits of receiving the recommended vaccines during pregnancy and also the potential risks it may pose to the developing fetus.
Advertisement
Results of this novel approach strongly suggest that the combination of an adequate skin treatment with a vaccine specifically designed to target skin immune cells could become a powerful tool for mass vaccination. The findings should be further investigated in clinical trials. Vogt concluded, "If we learn how to better reach and communicate with skin immune cells from the outside, we would be able to develop new tools for the treatment of allergies, inflammatory skin diseases or skin cancer."
Source: Medindia
Should Acetaminophen be Given Routinely After Vaccination in Infants?
Acetaminophen post vaccination in infants cannot be recommended due to its very low incidence of febrile seizures post vaccination and its interference with immunity.
Advertisement
 Childhood Vaccinations-Why Are They So Important?Know why it's extremely important to get your child vaccinated. Read on... | Advertisement
|
Advertisement
Recommended Reading
Latest Research News
Injury to the white matter explains why football players are at an increased risk for cognitive and behavioral problems later in life.
Located at the South Col, the rocky area between Mount Everest and Lhotse serves as the final campsite for climbers as well as a frozen legacy of hardy microbes.
The new finding is found to be valuable for screening specific medications and treatment against Giardia and other protozoan parasites.
New CRISPR genome-editing strategy was found to have a positive impact in the treatment of inherited retinal diseases such as retinitis pigmentosa.
H3N2 Influenza: The newly developed RT-qPCR Kit to identify influenza, COVID-19 and respiratory virus has got approval from ICMR.