About Careers MedBlog Contact us

Needle-Free Vaccination Could Now be Possible

by Dr. Trupti Shirole on February 19, 2015 at 4:07 PM
Font : A-A+

 Needle-Free Vaccination Could Now be Possible

Needle-free vaccination that can stimulate the immune response of the human skin is now possible, revealed a research published in Experimental Dermatology.

Vaccination is an effective method of stimulating the human body's immune system to fight against various pathogens such as bacteria and viruses. There is a need for safe, easy-to-use and inexpensive tools for vaccine administration. The immune system of the skin is a promising target as the skin lies directly in front of us.


Researcher Annika Vogt said, "For 10 years, we have been working together on how to use the skin immune system to develop a new, non-invasive vaccination method and in this study, we show how a painless method helps such vaccines cross the skin. The method wakes up skin immune cells so that they are ready to catch the vaccine and generate an immune response."

To make this discovery, the researchers treated natural skin samples with a novel method called cyanoacrylate skin surface stripping (CSSS). They then applied 200 nm particles to the skin surface and used microscopy to compare the penetration of the particles. The particle size reflects the size of viruses and engineered particulate vaccines. They found that the CSSS method enhanced the penetration of the particles to the deeper skin layers, especially to the hair follicles, and activated skin dendritic cells which are key players in the orchestration of the skin immune system.

Results of this novel approach strongly suggest that the combination of an adequate skin treatment with a vaccine specifically designed to target skin immune cells could become a powerful tool for mass vaccination. The findings should be further investigated in clinical trials. Vogt concluded, "If we learn how to better reach and communicate with skin immune cells from the outside, we would be able to develop new tools for the treatment of allergies, inflammatory skin diseases or skin cancer."

Source: Medindia


Recommended Reading

Latest Research News

Tackling Football at Young Age: A Risk for Brain Decline Later
Injury to the white matter explains why football players are at an increased risk for cognitive and behavioral problems later in life.
Frozen Frontier: Humans Leave a Unique Microbial Mark on Mount Everest
Located at the South Col, the rocky area between Mount Everest and Lhotse serves as the final campsite for climbers as well as a frozen legacy of hardy microbes.
How Does Protein Synthesis in Diarrhea Causing Parasite Work?
The new finding is found to be valuable for screening specific medications and treatment against Giardia and other protozoan parasites.
Unlocking the Potential of CRISPR for Reversing Vision Loss
New CRISPR genome-editing strategy was found to have a positive impact in the treatment of inherited retinal diseases such as retinitis pigmentosa.
 New RT-qPCR Kit Detects Influenza, COVID-19
H3N2 Influenza: The newly developed RT-qPCR Kit to identify influenza, COVID-19 and respiratory virus has got approval from ICMR.
View All
This site uses cookies to deliver our services.By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use  Ok, Got it. Close

Needle-Free Vaccination Could Now be Possible Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests