Medindia
Advertisement

Naturally Occurring 'Humanin Peptide' may Hold Cure for TBI, Heart Attack, Stroke

by Dr. Trupti Shirole on February 9, 2015 at 4:58 PM

 Naturally Occurring 'Humanin Peptide' may Hold Cure for TBI, Heart Attack, Stroke
Researchers at Ben Gurion University of the Negev have discovered that derivatives of a peptide called 'humanin', may hold cure for necrosis-related diseases such as traumatic brain injuries (TBI), myocardial infarction and stroke. These findings could provide a new lead compound for the development of drug therapies for these diseases.

Strokes, heart attacks and TBIs are separate diseases with certain shared pathologies that achieve a common end, cell death and human injury due to hypoxia, or lack of oxygen. In all these diseases, a lack of blood supply to affected tissues begins a signaling pathway that ultimately halts the production of energy-releasing ATP molecules, a death sentence for most cells.
Advertisement

By employing derivatives of humanin, a naturally occurring peptide encoded in the genome of cellular mitochondria, researchers are working to interrupt this process, thus buying precious time for tissues whose cellular mechanisms have called it quits. They work by counteracting the decrease in ATP levels caused by necrosis. The researchers tested the effectiveness of the humanin analogues AGA(C8R)-HNG17 and AGA-HNG by treating neuronal cells with these peptides prior to exposure to a necrotic agent, and the experiments were a success.

Researchers also performed in vivo studies by treating mice that had had TBIs with an HNG17 analogue, which successfully reduced cranial fluid buildup and lowered the mice's neuronal severity scores, a metric in which a higher number corresponds with greater degrees of neurological motor impairment.
Advertisement

As the peptides used during the experiment are derivatives of naturally occurring humanin, an ideal treatment might involve a drug delivery system with the HNG17 as the lead compound, a process aided by the ability of the peptides to penetrate the cell membrane without the use of additional reagents.

Source: Medindia
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
'Hybrid Immunity' may Help Elude COVID-19 Pandemic
Stroop Effect
Plant-Based Diet may Reduce the Risk of COVID-19
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Bell´s Palsy Diet Lifestyle and Heart Disease Mitral Valve Stenosis And Mitral Valve Replacement Congenital Heart Disease Stress and the Gender Divide Stroke Facts Stroke Heart Healthy Heart Hyperventilation 

Recommended Reading
Heart Attack- Lifestyle risks
Heart attack is the death of the heart muscle due to loss of blood supply. Simple guidelines to ......
Stroke
Stroke can cause permanent disability and it is important to recognize its early warning signs to .....
Tips to Prevent Heart Attacks
Heart Attack occurs when the flow of oxygenated blood to heart muscles is hindered or stopped due .....
How to Deal with a Stroke
Stroke is a brain attack, which occurs when the blood supply to the brain is interrupted. It ......
Congenital Heart Disease
Heart diseases that are present at birth are called “ Congenital heart diseases”....
Hyperventilation
Hyperventilation occurs when a person breathes in excess to the body’s requirement....
Mitral Valve Stenosis And Mitral Valve Replacement
Mitral valve replacement is a surgical heart procedure to correct either the narrowing (stenosis) or...
Stress and the Gender Divide
Stress has become entwined in the current lifestyle of a young working couple and has resulted in th...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use