"I really do have to say ... it really is a miracle time. It's a miracle night for me. I never thought I'd be standing here healthy and whole and 100 percent," People magazine quoted her as telling the crowd present.
The singer was diagnosed with Hepatitis C in April last year.
Apart from treating the liver disease with chemotherapy, she also battled kidney problems later that year.
However, she was back with a bang at the Hollywood Bowl belting out hits like 'This Will Be,' 'Our Love,' and 'Unforgettable'
She said: "My heart is very full tonight, and I know a lot of you know why. It's just good to be back. You know what I'm saying?
"You know, things don't always go the way we want it to. Things happen unexpectedly. You got to take the good with the bad."
Cole also brought the attention of the audience to health problems.
She said: "One in eight people has kidney failure. That's a lot of people and I never thought it would happen to me, but here we are."
She described the phase she was ill as "a real tough journey."