by Rathi Manohar on  April 12, 2011 at 11:08 PM Drug News
 Nasal Spray More Effective in Fighting Against Infections
A nasal spray that builds up resistance to infectious diseases right in the nasal has been developed by researchers at the Albany Medical College in New York.

By building up resistance right in the nasal passage, the spray stops the infection from taking root in the body, making it more effective than an injection. Along with standard vaccines for respiratory pathogens, a natural immune chemical, interleukin-12 (IL-12) [cytokine] is used to make it stronger when it is inhaled.

It affords a high level of protection against influenza virus, pneumococcal bacteria, and even bioterrorism threats like Yersinia pestis, which causes the plague. Nasal vaccines protect the pulmonary tract after pathogen exposure, which is a big benefit in the case of a bioterrorism threat or an influenza pandemic.

Dr. Dennis Metzger says,"Intranasal vaccination gets around this problem by inducing immunity in the pulmonary passage. This prevents initial infection as well as systemic complications."

Source: Medindia

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