Photophobia or light sensitivity is one of the symptoms of migraine headaches, which affects nearly 15% of the world's population. Exposing migraine sufferers to a narrow band of green light experience significantly reduces photophobia and can even reduce headache severity, says a new study led by researchers at Beth Israel Deaconess Medical Center (BIDMC).
"Although photophobia is not usually as incapacitating as headache pain itself, the inability to endure light can be disabling," said lead author Rami Burstein, PhD, Vice Chair of Research in the Department of Anesthesia, Critical Care and Pain Medicine and Academic Director of the Comprehensive Headache Center at BIDMC, as well as the John Hedley-Whyte Professor of Anesthesia at Harvard Medical School (HMS). "More than 80 percent of migraine attacks are associated with and exacerbated by light sensitivity, leading many migraine sufferers to seek the comfort of darkness and isolate themselves from work, family, and everyday activities."
Five years ago, Burstein and colleagues made the surprising discovery that blue light hurts migraine patients who are blind. This finding prompted the thinking that abnormal sensitivity to light during a migraine could be alleviated by blocking blue light. However, because that study involved only blind patients, who cannot detect all colors of light, Burstein, and his colleagues devised a way to study the effects of different colors of light on headache in patients without visual impairment.
To understand exactly why green light causes far less pain to patients with migraines, Burstein and colleagues designed experiments in which they measured the magnitude of the electrical signals generated by the retina (in the eye) and the cortex (in the brain) of these patients in response to each color of light. They found that blue and red lights generated the largest signals in both the retina and the cortex and that green light generated the smallest signals.
Next, applying innovative techniques recently developed by Rodrigo Noseda, PhD, also of BIDMC and Assistant Professor at HMS, they used animal models of a migraine to study neurons in the thalamus, an area of the brain that transmits information about light from the eye to the cortex. These neurons were found to be most responsive to blue light and least responsive to green light, explaining why the migraine brain responds favorably to green light.
"These findings offer real hope to patients with migraines and a promising path forward for researchers and clinicians," said Burstein.
Burstein is now working to develop a more affordable light bulb that emits "pure" (narrow band wavelength) green light at low intensity, as well as affordable sunglasses that block all but this narrow band of pure green light. Currently, the cost of one such light bulb is prohibitively high, and the technology to block all but pure green light in sunglasses is available only in light microscopy, which is also very costly.
The study is published in the journal Brain.