About Careers MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

Nanotechnology To Reduce Rejection Of Implants

by Gopalan on November 30, 2011 at 7:12 AM
Font : A-A+

 Nanotechnology To Reduce Rejection Of Implants

Nanotechnology can come in handy to reduce chances of rejection of implants like hip replacements and pacemakers, say researchers at the University of Gothenburg.

"Activation of the body's innate immune system is one of the most common reasons for an implant being rejected," explains Professor Hans Elwing from the University of Gothenburg's Department of Cell and Molecular Biology. "We can now show why the body more easily integrates implants with a nanostructured surface than a smooth one."

Advertisement

The researchers used a unique method to produce nanostructures on gold surfaces, creating gold particles just 10-18 nm in diameter and binding them to a completely smooth gold surface at carefully regulated distances. The result is something akin to a cobbled street in miniature.

Giving implants this cobbled surface reduces the activation of important parts of the innate immune system. This is because several of the proteins involved are of a similar size to these nanosized cobbles, and so do not change in appearance when they land on the surface. This gives the body a greater ability to integrate foreign objects such as implants, pacemakers and drug capsules into its own tissues, as well as reducing the risk of local inflammation.
Advertisement

"It may be that the innate immune system is designed to react to smooth surfaces, because these are not found naturally in the body," says Elwing. "Some bacteria, on the other hand, do have a completely smooth surface."

Modern nanotechnology makes it easy and cheap to surface-treat implants and drug capsules, but it will probably be several years before this becomes a reality in human medicine. The focus now is on customising titanium implants of various kinds.

 "We've developed a graded surface with different cobbelstone package that we think can be used for bone implants," says Elwing. "Bone is very hard on the outside but then gets softer, so it would be good to have hard integration on the surface and softer integration underneath. We reckon we can make titanium screws that are denser at the head of the screw so that they fuse best at the top. This kind of customisation is the future."

Research into the body's innate immune system was rewarded this year with the Nobel Prize in Physiology or Medicine.

The results are presented in the International Journal of Nanomedicine.



Source: Medindia
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Test  Your Knowledge on Heart
Test Your Knowlege on Genes
Obesity in Teens Make Inroads into Early Atrial Fibrillation
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Nanotechnology Use of Nanotechnology in Healthcare 

Most Popular on Medindia

Blood - Sugar Chart Indian Medical Journals Daily Calorie Requirements Find a Doctor Loram (2 mg) (Lorazepam) Accident and Trauma Care How to Reduce School Bag Weight - Simple Tips Post-Nasal Drip Turmeric Powder - Health Benefits, Uses & Side Effects Calculate Ideal Weight for Infants
This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
×

Nanotechnology To Reduce Rejection Of Implants Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests