About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Nanoparticles may Effectively Treat Antibiotic Resistance

by Bidita Debnath on December 16, 2017 at 11:57 PM
Font : A-A+

Nanoparticles may Effectively Treat Antibiotic Resistance

Mucoviscidosis, also known as cystic fibrosis, is an inherited life-threatening disorder that damages the lungs and digestive system. More than 70,000 people are suffering from Cystic fibrosis or Mucoviscidosis worldwide.

Scientists have succeeded in developing an effective method to treat the often lethal airway infections with nanoparticles that transport the antibiotics more efficiently to their destination. The lung is so significantly damaged that patients often die or need to have a lung transplant. Permanent treatment with inhaled antibiotics plays a considerable part in this.

Advertisement


While, the treatment can not avoid the colonisation by bacteria completely but it can keep it in check for a longer period of time.

The bacteria defends themselves with a development of resistance, but with the growth of so-called biofilms underneath the layer of mucus, which mostly block off the bacteria in the lower rows like a protective shield.
Advertisement

"Typically, the drugs are applied by inhalation in the body. Then they make a complicated way through the body to the pathogens and many of them don't make it to their destination," Dagmar Fischer, Chair for Pharmaceutical Technology at the University of Jena, in Germany, said in a statement.

To overcome the strong defense, the researchers encapsulated the active agents, like the antibiotic Tobramycin, in a polyester polymer.

Thus, they created a nanoparticle which they then tested in the laboratory where they beforehand had simulated the present lung situation, in a static as well as in a dynamic state, i.e. with simulated flow movements.

The scientists discovered that their nanoparticle travels more easily through the sponge-like net of the mucus layer and is finally able to kill off the pathogens without any problems.

Moreover, an additionally applied coating of polyethylenglycol makes it nearly invisible for the immune system.

"All materials of a nanocarrier are biocompatible, biodegradable, nontoxic and therefore not dangerous for humans," the researchers noted.

Source: IANS
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
International Day of Persons with Disabilities 2021 - Fighting for Rights in the Post-COVID Era
Effect of Blood Group Type on COVID-19 Risk and Severity
Woman with Rare Spinal Cord Defect from Birth Sues Doctor
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
MRSA - The Super Bug Drug Resistance - Antibiotic Resistance Antibiotics Nanotechnology Eye Infections Natural Antibiotics to Fight Bacterial Infections Vancomycin-Resistant Enterococci (VRE) Boils - Treatment by Drugs Multiple Drug Allergy Syndrome Interaction of Antibiotics with Dairy Products 

Recommended Reading
New Weapons Discovered Promise to Fight Against Antibiotic Resistance
Bacterial strains interact differently by making themselves more or less resistant to antibiotics. ....
A Few Tricks in Drug Targets can Prevent Antibiotic Resistance
Tricking the bacteria using specific cell receptors can prevent antibiotic resistance in them. To .....
Antibiotics Prior to Surgery Not a Risk Factor for Postop Antibiotic Resistance
Prescription of antibiotics prior to low-risk operations, not at an increased risk for ......
Drug Use in Animal Farming, Meat Production Causes Antibiotic Resistance
Continuing to use medically important antibiotics for growth promotion in animals is one main ......
Antibiotics
Antibiotics are among the most used and abused medications. This article explains some general featu...
Boils - Treatment by Drugs
Diabetes patients have reduced immunity, which makes them more susceptible to skin infections like b...
Drug Resistance - Antibiotic Resistance
Drug resistance is often a problem in malaria, tuberculosis, HIV, sexually transmitted diseases and ...
Eye Infections
Eye infection is a common problem that often causes pain and discomfort to the eyes. Common symptoms...
Interaction of Antibiotics with Dairy Products
Antibiotics like tetracyclines and fluoroquinolones used in the treatment of bacterial infections in...
MRSA - The Super Bug
MRSA infection is the most dreaded hospital or community acquired infection that can become ......
Multiple Drug Allergy Syndrome
Multiple drug allergy syndrome or multiple drug hypersensitivity syndrome is a condition that causes...
Natural Antibiotics to Fight Bacterial Infections
Fighting infections the natural way and preventing them is always more effective than consuming medi...
Vancomycin-Resistant Enterococci (VRE)
Enterococci are a group of gram-negative bacteria that mostly inhabit the human gut. At present ther...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use