Mucoviscidosis, also known as cystic fibrosis, is an inherited life-threatening disorder that damages the lungs and digestive system. More than 70,000 people are suffering from Cystic fibrosis or Mucoviscidosis worldwide.
Scientists have succeeded in developing an effective method to treat the often lethal airway infections with nanoparticles that transport the antibiotics more efficiently to their destination. The lung is so significantly damaged that patients often die or need to have a lung transplant. Permanent treatment with inhaled antibiotics plays a considerable part in this.
New Weapons Discovered Promise to Fight Against Antibiotic Resistance
Bacterial strains interact differently by making themselves more or less resistant to antibiotics. New antibiotics can be developed to enhance antibiotic susceptibility.
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‘After cystic fibrosis, the lung gets damaged and patients often die or need to have a lung transplant. Permanent treatment with inhaled antibiotics play a considerable part.’
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While, the treatment can not avoid the colonisation by bacteria completely but it can keep it in check for a longer period of time.
The bacteria defends themselves with a development of resistance, but with the growth of so-called biofilms underneath the layer of mucus, which mostly block off the bacteria in the lower rows like a protective shield.
![A Few Tricks in Drug Targets can Prevent Antibiotic Resistance]( "A Few Tricks in Drug Targets can Prevent Antibiotic Resistance")
Tricking the bacteria using specific cell receptors can prevent antibiotic resistance in them. To deceive them, they could feed misinformation to its chemoreceptors.
"Typically, the drugs are applied by inhalation in the body. Then they make a complicated way through the body to the pathogens and many of them don't make it to their destination," Dagmar Fischer, Chair for Pharmaceutical Technology at the University of Jena, in Germany, said in a statement.
To overcome the strong defense, the researchers encapsulated the active agents, like the antibiotic Tobramycin, in a polyester polymer.
Thus, they created a nanoparticle which they then tested in the laboratory where they beforehand had simulated the present lung situation, in a static as well as in a dynamic state, i.e. with simulated flow movements.
The scientists discovered that their nanoparticle travels more easily through the sponge-like net of the mucus layer and is finally able to kill off the pathogens without any problems.
Moreover, an additionally applied coating of polyethylenglycol makes it nearly invisible for the immune system.
"All materials of a nanocarrier are biocompatible, biodegradable, nontoxic and therefore not dangerous for humans," the researchers noted.
Source: IANS
A Few Tricks in Drug Targets can Prevent Antibiotic Resistance
Tricking the bacteria using specific cell receptors can prevent antibiotic resistance in them. To deceive them, they could feed misinformation to its chemoreceptors.
Advertisement
"Typically, the drugs are applied by inhalation in the body. Then they make a complicated way through the body to the pathogens and many of them don't make it to their destination," Dagmar Fischer, Chair for Pharmaceutical Technology at the University of Jena, in Germany, said in a statement.
To overcome the strong defense, the researchers encapsulated the active agents, like the antibiotic Tobramycin, in a polyester polymer.
Thus, they created a nanoparticle which they then tested in the laboratory where they beforehand had simulated the present lung situation, in a static as well as in a dynamic state, i.e. with simulated flow movements.
The scientists discovered that their nanoparticle travels more easily through the sponge-like net of the mucus layer and is finally able to kill off the pathogens without any problems.
Moreover, an additionally applied coating of polyethylenglycol makes it nearly invisible for the immune system.
"All materials of a nanocarrier are biocompatible, biodegradable, nontoxic and therefore not dangerous for humans," the researchers noted.
Source: IANS
Antibiotics Prior to Surgery Not a Risk Factor for Postop Antibiotic Resistance
Prescription of antibiotics prior to low-risk operations, not at an increased risk for antibiotic-resistant infections post-surgery, says study.
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 Drug Use in Animal Farming, Meat Production Causes Antibiotic ResistanceContinuing to use medically important antibiotics for growth promotion in animals is one main reason for antibiotic resistance to diseases. | Advertisement
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