Synthetic nanoparticles are an alternative for selective drug delivery to tumor cells that may improve efficacy and reduce adverse side effects of cancer therapies.

‘Nanoparticles are tiny spheres that are 1,000 times smaller than the width of a human hair and can improve the solubility and delivery of drugs to cells.’

“The discovery that nanoparticles can be selective to certain cells based only on their physical and chemical properties has profound implications for nanoparticle-based therapies because cell type specificity of drug carriers could alter patient outcomes in the clinic,” said corresponding author Dr. Daniel Siegwart, Assistant Professor of Biochemistry at UT Southwestern Medical Center and with Simmons Cancer Center.




“At the same time, a deeper understanding of nanoparticle interactions in the body opens the door to predict patient responses to existing liposome and nanoparticle therapies, and offers the potential to create future drug carriers customized according to individual genetic profiles.”
The findings appear in the Proceedings of the National Academy of Sciences. The scientists tested hundreds of polymers to make the surprising discovery that cells could respond differently to the same drug carrier, even when those cancerous and normal cells came from the lungs of the same patient.
“These functional polyester nanoparticles provide an exciting alternative approach for selective drug delivery to tumor cells that may improve efficacy and reduce adverse side effects of cancer therapies,” said co-author Dr. John Minna, Professor and Director of the Nancy B. and Jake L. Hamon Center for Therapeutic Oncology Research, and Director of the W.A. “Tex” and Deborah Moncrief Jr. Center for Cancer Genetics at UT Southwestern.
The researchers developed new chemical reactions to create a diverse library of polymers that could deliver nucleic acid drugs while possessing enough structural diversity to discover cancer cell-specific nanoparticles. This is an important step to improving tailored cancer therapies to an individual’s specific genetic makeup.
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“It is already possible to use genetic sequencing to customize drug regimens for each patient. We may also be able to customize the drug carrier to predictably improve patient responses.”
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Amazingly, the cancer selective nanoparticles stayed inside of tumors in mice for more than one week, while nonselective control nanoparticles were cleared within a few hours. This translated to improved siRNA-mediated cancer cell death and significant suppression of tumor growth.
Support for this latest research came from the Cancer Prevention and Research Institute of Texas (CPRIT), Welch Foundation, American Cancer Society, UTSW’s Friends of the Comprehensive Cancer Center, the UTSW Translational Pilot Program, and the NIH National Cancer Institute SPORE grant in Lung Cancer.
Source-Newswise