The risk of breast cancer mutations among Asian women is highly underestimated, according to oncologists at the Stanford University School of Medicine. Allison Kurian, MD, and her colleagues at the Stanford University School of Medicine were perplexed. Computer models designed to identify women who might have dangerous genetic mutations that increase their risk of breast and ovarian cancer worked well for white women. But they seemed to be less reliable for another ethnic group.
In the study, Allison Kurian, MD, used computer models designed to identify women who might have dangerous genetic mutations that increase their risk of breast and ovarian cancer
However, they were taken by surprise when they found that in a head-to-head comparison between whites and Asians, two of the most commonly used computer models failed in predicting the presence of mutations in almost half of the Asian women studied.
"We've been repeatedly surprised when Asian women who the models predicted would probably not have the mutations do in fact have them," said Kurian.
She added: "Doctors and patients should have a higher level of suspicion when using these prediction models in Asian women, because they under-predicted the true number of clinically important mutations. We may have to consider more subtle patterns of family cancer history when considering genetic testing in this ethnic group."
While it is believed that mutations in two genes - BRCA1 and BRCA2 are linked to the development of breast or ovarian cancer in carriers, it was found that, not every woman with a family history of cancer or who develops these cancers has these mutations.
They sequenced the BRCA1 and BRCA2 genes of all of the study subjects and compared them to the models' predictions.
However, both programs performed much worse in predicting the 49 Asian women in the study sample with mutations. One program predicted that only 25 of the 49 women would carry mutations, while the other recommended testing of 26 women.
"It's clear that these models are far from foolproof. These results emphasize the need for expert evaluation by a genetics professional to guide all clinical genetic testing," said Kurian, who is also a member of the Stanford Cancer Center.
The study results point out the need for further investigation into the genetic variability of different ethnic groups.
In addition to previously identified, clinically important mutations of the genes, the researchers identified more "variants of unknown significance" in the BRCA1 and BRCA2 genes of Asian women than in white women.
Many of these variants probably don't have any clinical effect. We know a lot more about the normal variability of these genes in white women. Many of these variants are probably just normal for members of a particular ethnic group, but we haven't studied enough people in ethnic minority groups to know for sure, and further research needs to be done to distinguish variants of uncertain significance from truly harmful mutations," said Kurian.
The study was published online in the Journal of Clinical Oncology.