About Careers Internship MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

Mutation of Cancer Causing BAP1 Gene Passed Down Over Centuries

by Dr. Trupti Shirole on December 24, 2015 at 11:09 PM
Font : A-A+

 Mutation of Cancer Causing BAP1 Gene Passed Down Over Centuries

Mutation of a gene called BAP1 has been linked to development of mesothelioma, melanoma, renal carcinoma and other cancers. University of Hawaii Cancer Center researchers discovered members of four families, apparently unrelated and living in different states across the US, shared the identical mutation of BAP1.

This raised two possibilities for the researchers- these four families were related although they did not know it, or researchers had found a hot spot for BAP1 mutations.

Advertisement


In the findings published in PLOS Genetics, through genetic and genealogical studies by Dr. Michele Carbone, director of the UH Cancer Center's Thoracic Oncology Program and colleagues, it was demonstrated that the family members were related and that they descended from a couple that immigrated to the US from Germany in the early 1700's.

Dr. Carbone said, "For about three years we traveled across the US and the world to find evidence that linked these four families, their ancestors and descendants in a large family tree of about 80,000 people."
Advertisement

The research team found the European ancestors of the couple that immigrated to the US in the 1700s and some of their descendants who are still living in the original home built in the 1400s in Switzerland. The research team anticipates finding many other family members from the family tree who have inherited the mutation.

Dr. Carbone further added, "These descendants can be tested for BAP1 mutations, and if they are found to have inherited the mutation they can be followed for cancer prevention and also for early detection. For some of the cancer types this would be life saving. Moreover, early detection of mesothelioma, and of other cancers that develop in BAP1 carriers are associated with much better survival."

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Alarming Cesarean Section Trends in India - Convenience or Compulsion of Corporate Healthcare
Quiz on Low-Calorie Diet for Diabetes
World Heart Day in 2022- Use Heart for Every Heart
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
DNA Finger Printing Cancer and Homeopathy Cancer Facts Cancer Tattoos A Body Art McArdle Disease Weaver Syndrome Common Lifestyle Habits that Cause Diseases Health Benefits of Dandelion Plant Immune Checkpoint Inhibitors for Cancer Treatment 

Most Popular on Medindia

Sanatogen How to Reduce School Bag Weight - Simple Tips Loram (2 mg) (Lorazepam) Blood Pressure Calculator Indian Medical Journals Iron Intake Calculator Nutam (400mg) (Piracetam) A-Z Drug Brands in India Sinopril (2mg) (Lacidipine) Accident and Trauma Care
This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
×

Mutation of Cancer Causing BAP1 Gene Passed Down Over Centuries Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests