About My Health Careers Internship MedBlogs Contact us

Mutant P53 Gene Fuels Cancer-promoting Effects of Inflammation

by Anjali Aryamvally on October 22, 2017 at 12:15 PM
Font : A-A+

Mutant P53 Gene Fuels Cancer-promoting Effects of Inflammation

p53, a human tumor suppressor gene which is commonly known as the "guardian of the genome," is a key gene that combats the formation and progression of tumors. However, mutations in the p53 have been linked to maximum cases of human cancer than any other gene.

Investigating core mechanisms of how cancer cells respond to their surroundings in the human body, biologists at the University of California San Diego have discovered new evidence about mutant p53 that may reshape our understanding of tumor growth and ultimately how we treat cancer.


A study published in the journal Nature Communications led by Homa Rahnamoun in Shannon Lauberth's laboratory at UC San Diego's Division of Biological Sciences uncovered a new mechanism linking mutant p53 function to chronic inflammation -- a long-term condition typically associated with a response in the body's immune system--which can be induced in situations ranging from stress to food consumption. Lauberth said increasing evidence supports the role of chronic inflammation in the predisposition and progression of cancer, with some human tissues being more susceptible to tumor growth influenced by inflammation, including colon and breast cancers.

Through large-scale genomic analyses, the research team discovered that mutant p53 amplifies the impact of inflammation leading to increases in the invasive behavior of cancer. Thus, rather than fighting tumor growth, mutant forms of p53 appear to be tapping into the body's immune response system to fuel pro-inflammatory responses that increase cancer growth.

"Our findings suggest the importance of considering the genetic alterations of an individual's cancer since this can influence the impact of inflammation on human cancer," said Lauberth, an assistant professor in the Section of Molecular Biology. "Immune therapy has been helpful in terms of targeting cancer and decreasing tumor size but now we found that inflammatory mediators can instead orchestrate growth in cancer cells harboring a mutation in p53. These findings make us really rethink the process of tumorigenesis and how we treat cancer."

Lauberth says this research can potentially help better define clinically relevant cellular targets and their responses in human cancer with the ultimate goal of aiding the development of target-based cancer screening and therapies.

Source: Eurekalert

News A-Z
News Category
What's New on Medindia
Printed Temperature Sensors help with Continuous Temperature Monitoring
Health Benefits of Giloy
Breast Cancer Awareness Month 2021 - It's time to RISE
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
DNA Finger Printing Weaver Syndrome Anti-Inflammatory Diet Inflammation Top Ten Foods That Trigger Inflammation 

Recommended Reading
Stanford-led Study Uncovers Secrets of P53 Tumor Suppressor
Mutation in the p53 tumor suppressor has been recently uncovered by a Stanford-led study. The study ...
P53 Protein Critical to Recovering from Acetaminophen Overdose
Insights into protein that links liver-injury progression and repair could lead to new treatments....
African American Women With P53 Genetic Variant Have Elevated Breast Cancer Risk
The p53 protein is a critical tumor suppressor in the cell and genetic mutations cause a loss of ......
Anti-Cancer Molecule P53 in Tumors Can Be Reawakened
The cancer-fighting molecule p53 plays a key role in preventing tumor initiation and progression by ...
Anti-Inflammatory Diet
Healthy foods as part of anti-inflammatory diet to fight inflammation are basic components of the Me...
DNA Finger Printing
DNA fingerprinting is a technique which helps forensic scientists and legal experts solve crimes, id...
Inflammation is the response of living tissue to injury due to a variety of causes that call upon ho...
Top Ten Foods That Trigger Inflammation
Foods like refined carbohydrates, sugar, certain types of fat, artificial food additives and alcohol...
Weaver Syndrome
Weaver syndrome is a genetic disorder in which children show accelerated bone growth, advanced bone ...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use