Acinetobacter baumannii, a gram-negative bacteria may cause severe infections in children. The effect of antibiotics such as cephalosporin and carbapenem were examined to treat A. baumannii infection in children.
In the first national study of the prevalence of antibiotic-resistant Acinetobacter baumannii infections in children across the US, researchers from Center for Disease Dynamics, Economics, & Policy (CDDEP) in Washington, DC and Rush University in Chicago, IL examined national and regional trends of antibiotic resistance in clinical specimens over a 13-year period.
Multidrug Resistant Bacteria’s Latest Mechanism To Block Colistin Revealed
Multidrug resistant Acinetobacter baumannii's mechanism of resisting colistin, the antibiotic used in hospital-acquired infections has been discovered.
Advertisement
‘The treatment for infections caused by drug-susceptible A. baumannii is hard to treat. The effect of cephalosporin and carbapenem, a multi-drug resistance treatment was used to combat A. baumannii infections.’
Tweet it Now
While there was an overall increase between 1999 and 2012 in the proportion of isolates of A. baumannii that were resistant to cephalosporin and carbapenem, the authors noted a slight decline after a peak in 2008.
The decrease may be attributable to a combination of antibiotic stewardship guidelines released in 2007 and infection control guidance specifically designed to combat multi-drug resistant A. baumannii in healthcare settings.
![Efforts Needed to Stop the Spread of Acinetobacter Baumannii Infections in Europe]( "Efforts Needed to Stop the Spread of Acinetobacter Baumannii Infections in Europe")
Acinetobacter baumannii is the cause of difficult-to-treat infections in healthcare settings in Europe due to its increasing resistance to antimicrobial agents.
Infections caused by drug-susceptible A. baumannii are difficult to treat and the emergence of resistance has made treatment even more challenging. Highly resistant A. baumannii infections are increasingly being reported worldwide.
The study found that the crude proportion of cephalosporin-resistant A. baumannii increased from 13.2% in 1999 to 23.4% in 2012, whereas the proportion of carbapenem-resistant A. baumannii increased from 0.6% in 1999 to 6.1% in 2012. From 1999 to 2012, the proportion of cephalosporin-resistant and carbapenem-resistant A. baumannii increased each year by 3% and 8%, respectively; however, after 2008, a downward trend was observed, but resistance remained higher than was observed in 1999.
"Acinetobacter are bacteria known to cause serious infections that are notoriously difficult to treat because of growing antibiotic resistance," according to Dr. Latania K. Logan of Rush University Medical Center.
"The bacteria survive for long periods in the environment. Further studies are needed to assess the most effective prevention strategies in children, who are particularly vulnerable to A. baumannii."
"It is encouraging to see a downtrend after 2008, but we need to continue to monitor resistance trends," said study co-author Dr. Sumanth Gandra of CDDEP. "The lack of new drugs to treat Acinetobacter remains a concern," he said.
Source: Eurekalert
Efforts Needed to Stop the Spread of Acinetobacter Baumannii Infections in Europe
Acinetobacter baumannii is the cause of difficult-to-treat infections in healthcare settings in Europe due to its increasing resistance to antimicrobial agents.
Advertisement
Infections caused by drug-susceptible A. baumannii are difficult to treat and the emergence of resistance has made treatment even more challenging. Highly resistant A. baumannii infections are increasingly being reported worldwide.
The study found that the crude proportion of cephalosporin-resistant A. baumannii increased from 13.2% in 1999 to 23.4% in 2012, whereas the proportion of carbapenem-resistant A. baumannii increased from 0.6% in 1999 to 6.1% in 2012. From 1999 to 2012, the proportion of cephalosporin-resistant and carbapenem-resistant A. baumannii increased each year by 3% and 8%, respectively; however, after 2008, a downward trend was observed, but resistance remained higher than was observed in 1999.
"Acinetobacter are bacteria known to cause serious infections that are notoriously difficult to treat because of growing antibiotic resistance," according to Dr. Latania K. Logan of Rush University Medical Center.
"The bacteria survive for long periods in the environment. Further studies are needed to assess the most effective prevention strategies in children, who are particularly vulnerable to A. baumannii."
"It is encouraging to see a downtrend after 2008, but we need to continue to monitor resistance trends," said study co-author Dr. Sumanth Gandra of CDDEP. "The lack of new drugs to treat Acinetobacter remains a concern," he said.
Source: Eurekalert
Spread of Drug-resistant Bacteria Can Be Prevented
The spread of drug-resistant bacteria can be prevented with proper communication between the health care facilities and patients infected by A. baummanii .
Advertisement
 Against A. Baumannii Hospital Cleaning Protocol IneffectiveTo rid patient rooms of multidrug-resistant (MDR) Acinetobacter baumannii , current hospital cleaning protocol may be inadequate. | Advertisement
|
Advertisement
Recommended Readings
Latest Drug News
The psychedelic market set for remarkable growth, projected to hit $7.2B by 2029 with a strong 55% CAGR.
The study explores whether CDNF could influence the progression of ALS in rodent models and to elucidate the mechanism through which it operates.
Amoxicillin-clavulanate use in acute sinusitis patients is associated with a higher incidence of adverse events.
Professionals advocate for enhanced education of patients and caregivers, and creation of more effective child-resistant systems for monitoring ADHD medication.
In June, WHO raised concerns about 7 Indian cough syrups after complaints from several countries about contamination and health issues.
