About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

MRSA Strain Got Help from Skin Bacteria, Rose to Prominence

by Dr. Enozia Vakil on December 18, 2013 at 2:48 PM
Font : A-A+

 MRSA Strain Got Help from Skin Bacteria, Rose to Prominence

Researchers believe they may have found out why methicillin-resistant Staphylococcus aureus (MRSA) has rapidly risen and become prominent. Research published in mBioŪ, the online open-access journal of the American Society for Microbiology, suggests that the strain recently acquired a number of genes from common skin bacteria that allow it to grow and thrive on the skin where other strains of MRSA cannot.

"Over the past 15 years, methicillin-resistant Staphylococcus aureus has become a major public health problem. It is likely that adaptations in specific MRSA lineages drove the spread of MRSA across the United States and allowed it to replace other, less-virulent S. aureus strains," says Paul Planet of Columbia University, the lead author on the study.

Advertisement

Since it was first identified in the late 1990s the USA300 strain of MRSA has undergone an extremely rapid expansion across the United States. It is now the predominant cause of community-acquired MRSA skin and soft tissue infections and has been implicated in MRSA outbreaks among professional football teams. The strain is genetically distinguished from other strains by a cluster of genes known as the arginine catabolic mobile element (ACME.)

"Using phylogenetic analysis, we showed that the modular segments of ACME were assembled into a single genetic locus in Staphylococcus epidermidis (a relatively harmless bacterium typically found on human skin) and then horizontally transferred to the common ancestor of USA300 strains in an extremely recent event that coincided with the emergence and spread of this strain" says Planet.
Advertisement

The researchers identified one ACME gene in particular, called speG, that conferred on USA300 strains the ability to withstand high levels of polyamines, compounds produced by the skin that are toxic to other strains of MRSA. Polyamine tolerance also gave MRSA multiple advantages including enhanced biofilm formation, adherence to host tissues and resistance to certain antibiotics, according to the study.

"We suggest that these properties gave USA 300 a major selective advantage during skin infection and colonization, contributing to the extraordinary evolutionary success of this clone," says Planet.



Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
Sensory Processing Disorder (SPD)
First Dose of COVID-19 Vaccines May Improve Mental Health
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Boils / Skin Abscess Torticollis Pityriasis rosea Pemphigus Hives Scleroderma MRSA - The Super Bug Drug Resistance - Antibiotic Resistance Vitiligo Skin Self Examination 

Recommended Reading
Resistant MRSA Infections on the Rise
Pediatric musculoskeletal infections are evolving and more children are now being diagnosed with ......
MRSA Declines are Sustained in Veteran Hospitals
After implementing a national initiative to reduce methicillin-resistant Staphylococcus aureus
Nanosponge Vaccine Fights MRSA Toxins, Say Researchers
New nanosponge vaccine soaks up a dangerous pore-forming toxin produced by MRSA, say researchers....
Boils / Skin Abscess
Encyclopedia section of medindia gives general info about Boils / Skin Abscess ...
Drug Resistance - Antibiotic Resistance
Drug resistance is often a problem in malaria, tuberculosis, HIV, sexually transmitted diseases and ...
Hives
Hives or Urticaria are allergic skin reaction that appear suddenly in clusters or as single bumps on...
MRSA - The Super Bug
MRSA infection is the most dreaded hospital or community acquired infection that can become ......
Pemphigus
Pemphigus is a rare group of autoimmune diseases that affect the skin and mucous membranes causing b...
Pityriasis Rosea
Pityriasis rosea is a common skin disease that is not contagious. It manifests as oval-shaped, pink ...
Scleroderma
Scleroderma or CREST syndrome is a chronic, auto immune disease which manifests as thick, dry, fibro...
Skin Self Examination
The skin self examination means checking one’s own skin for any visible abnormal growths or unusual ...
Torticollis
Torticollis is abnormal tilted position of the head, with chin turned to the opposite side. It may o...
Vitiligo
Vitiligo is a skin disease characterized by patches of unpigmented skin. Vitiligo is usually slowly ...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use