About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Mouse Model to Evaluate Potential Age-Promoting Agents

by Bidita Debnath on December 18, 2013 at 10:40 PM
Font : A-A+

 Mouse Model to Evaluate Potential Age-Promoting Agents

To identify cancer-causing agents there are well-established mouse models, similar models are not available to readily test and identify age-promoting agents.

Recently, a mouse strain (p16LUC mice) was developed that can be used to evaluate the transcription of p16INK4, which is increasingly expressed during aging and in age-associated diseases. In this issue of the Journal of Clinical Investigation, Norman Sharpless and colleagues at the University of North Carolina evaluated potential age-promoting compounds, including arsenic, a high-fat diet, UV light, and cigarette smoke in p16LUC mice.

Advertisement

The authors found that a high fat diet did not accelerate p16INK4 expression, but both UV light exposure and cigarette smoke exposure dramatically increased p16INK4 expression compared to controls that had not been exposed to these age-promoting compounds. This study demonstrates that p16LUC mice are an appropriate model system for evaluating potential age-promoting compounds.

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
First-Ever Successful Pig-To-Human Kidney Transplantation
World Osteoporosis Day 2021 -
Spirituality and Mental Health
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.


Recommended Reading
Women and Cancer
Cancer is one of the frequently talked about and most feared disease that falls under the genre of ....
Pain Drugs Used During Prostate Cancer Removal may Affect Long Term Outcomes
Long term cancer outcomes may be affected by the use of method to anesthetize patients having ......
Coffee and Cancer?
One out of ten adults assume that there is a connection between coffee and cancer and a recent poll ...
Study Finds Radiation Therapy to Treat Uterine Cancer May Increase Bladder Cancer Risk Later in Life
A study finds radiation therapy used to treat uterine cancer may increase a patient's risk of ......

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use