A greater obesity duration is found to be associated with worse values for all cardiometabolic disease factors, stated a new study published this week in PLOS Medicine by Tom Norris of Loughborough University, UK, and colleagues.
People with obesity do not all share the same risk for the development of cardiometabolic disease risk factors. The duration a person has spent with obesity over their lifetime has been hypothesized to affect this variation.
In the new study, researchers used data from three British birth cohort studies that collected information on body mass index from age 10 to 40 as well as cardiometabolic disease risk factors--blood pressure, cholesterol and glycated hemoglobin (blood sugar) measurements--in 20,746 participants.
Importantly, this increased risk persisted when adjustment was made for a robust measure of life course obesity severity. Other measures of cardiometabolic disease risk (systolic and diastolic blood pressure, high density-lipoprotein cholesterol) were also associated with obesity duration, though these were largely attenuated when adjusting for obesity severity.