Medindia
Advertisement

More Benefits from Stem Cells

by Himabindu Venkatakrishnan on May 8, 2014 at 7:36 PM
Font : A-A+

 More Benefits from Stem Cells

Life-saving treatment commonly used in pediatric patients can help adults suffering from diseases such as leukemia, lymphoma, and other blood-related disorders. Researchers at the Icahn School of Medicine at Mount Sinai have identified a new technique that causes cord blood (CB) stems cells to generate in greater numbers making them more useful in adult transplantation.

The study, published in the May issue of The Journal of Clinical Investigation, looked at ways to expand the number of hematopoietic stem cells (HSC) in the laboratory required to replenish and renew blood cells. Cord blood stem cells have the ability to rapidly divide in the presence of combinations of growth factors but they often lose their marrow-repopulating potential following cell division. Researchers looked at ways to overcome this limitation by inducing a genetic program by which a stem cell retains its full functional properties after dividing in the laboratory.

Advertisement

"Cord blood stem cells have always posed limitations for adult patients because of the small number of stem cells present in a single collection," said Pratima Chaurasia, PhD, Assistant Professor of Medicine at the Tisch Cancer Institute at Mount Sinai. "These limitations have resulted in a high rate of graft failure and delayed engraftment in adult patients."

Researchers used a technique called epigenetic reprogramming which reshaped cell DNA by treating cells with a combination of histone deacetylase inhibitors (HDACI) and valproic acid. The VPA-treated cells produced a greater number of repopulating cells, and established multilineage hematopoiesis in primary, secondary and tertiary immune-deficient mice.
Advertisement

"We're excited by these results. The findings have important implications for patients battling blood cancers and the difference between success and failure of life saving stem cell transplants." added Ronald Hoffman, MD, Albert A. and Vera G. List Professor of Medicine, Director of Myeloproliferative Disorders Research Program at the Tisch Cancer Institute at Mount Sinai.

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
Sedentary Behavior Precipitates Night-Time Hot Flashes
Gonorrhea
World Alzheimer's Day 2021 - 'Know Dementia, Know Alzheimer's
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Stem Cells - Cord Blood Stem Cells - Fundamentals Parkinsons Disease Surgical Treatment Genetics and Stem Cells Bone Marrow Transplantation Tissue Engineering and Regenerative Medicine Stem Cells 

Recommended Reading
Researchers Identify How Heart Stem Cells Help Regenerate Healthy Tissue After Heart Attack
Investigators who previously showed that cardiac stem cell therapy reduces scarring and regenerates ...
Stem Cells - Fundamentals
Encyclopedia section of medindia gives general info about Stem Cells...
Use of Stem Cells in Personalized Medicine
Stem cell therapy, a leading topic of interest among the budding scientists. These cells play a ......
Novel Stem Cell Treatment for Corneal Blindness
A biodegradable contact lens filled with stem cells may be useful in the treatment of corneal ......
Bone Marrow Transplantation
Preferred Term is Hematopoietic stem cell transplantation. In this stem cell from bone marrow are in...
Stem Cells - Cord Blood
Encyclopedia section of medindia gives general info about Cord Blood...
Tissue Engineering and Regenerative Medicine
This new field is an amalgamation of biology, medicine and engineering, and is believed to have mind...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use