Molecular switch transducin beta-like (TBL) 1, appears to be a common feature in the development of fatty liver disease, say scientists. The discovery made in mice is consistent with data from human patients, suggesting that it may provide an underlying explanation for the development of fatty liver in people with obesity and metabolic syndrome. The culprit is the reduced concentration of a little-known transcriptional co-factor known as transducin beta-like (TBL) 1, according to the researchers. "We haven't entirely solved it yet, but we've seen that a lower abundance of TBL1 is common to multiple mouse models," said Stephan Herzig of DKFZ-ZMBH Alliance in Germany. "Most importantly, in human livers, the more fat there is the lower this transcriptional co-factor," he said. In the new study, Herzig's team went in search of components of that regulatory machinery that might be important in the case of fatty liver disease, a condition that is tightly associated with several components of metabolic syndrome, including diabetes and heart disease. "Fatty liver may be one reason for the further development of insulin resistance. It appears to contribute to some of the long-term complications and is an independent risk factor for cardiovascular complications," said Herzig. The researchers looked to mice with fatty liver disease of various genetic or dietary causes. In every case, those mice also showed impaired activity of TBL1 in the liver. When the researchers disabled TBL1 in the livers of healthy mice, they too went on to show high triglycerides and the buildup of fat in the liver. In human patients, TBL1 levels were also inversely related to the amount of fat in an individual's liver. In other words, as TBL1 levels go down, it appears that liver fat levels go up. The study appeared in the April issue of Cell Metabolism, a Cell Press publication.Source: ANI << Women Confused Over Recent Mammography Recommendations: Rep... 77 Percent of Patients Stop Anti-tremor Drugs After Deep Br... >> Recommended Reading Alcoholic Liver Disease Encyclopedia section of medindia gives general information about Alcoholic Liver Disease. READ MORE Quiz on Liver How many of us know that the liver is a vital organ the size of an American Football? To understand more about the liver and its functions spend a few minutes taking part in this ... READ MORE How to Lose Weight? Slide show which explains obesity causes and tips on how to lose weight. Exercising before breakfast is most effective for weight loss. READ MORE Hormone Pathway to Fatty Liver Disease Discovered UCSF Cardiovascular Research Institute scientists have uncovered the mechanism behind a change in growth hormone activity in mice leads to fatty liver disease. READ MORE Biliary Cirrhosis Biliary cirrhosis occurs due to obstruction to the flow of bile through bile ducts either within the liver or outside the liver. READ MORE Current Treatments for Liver Cancer Current Treatments for Liver Cancer (also known as hepatoma or hepatocellular carcinoma) can result in complete cure of the disease if it is detected early. READ MORE Fatty Liver Disease: A Growing Health Problem in India Non alcoholic fatty liver disease (NAFLD) is the leading cause of liver dysfunction worldwide and is a rapidly growing health problem in India. READ MORE Hepatitis A Hepatitis A is the most benign of the hepatitis viruses and usually has no long term side effects. Hepatitis A vaccine is available that is 95% effective in preventing the disease. READ MORE Living Donor Liver Transplant: What Are the Risks? The risk of dying as a result of a living donor liver segment removal is between 0.2-2.0%. The risk of morbidity is anywhere between 1.3% (in highly experienced centers) to 60%. READ MORE Milk Thistle Milk Thistle is a resourceful natural plant which has many medicinal benefits. In herbal medication milk thistle is used in cases of liver diseases. READ MORE Wilson's Disease This is a rare inherited systemic disorder of copper metabolism, affecting the liver mainly before other organs. READ MORE Most Popular on Medindia Sinopril (2mg) (Lacidipine) Blood - Sugar Chart Hearing Loss Calculator More News on: Alcoholic Liver DiseaseLiver BiopsyHepatitis ALiverWilson's DiseaseBiliary CirrhosisMilk ThistleCurrent Treatments for Liver CancerFatty Liver Disease: A Growing Health Problem in IndiaLiving Donor Liver Transplant: What Are the Risks?