About Careers Internship MedBlog Contact us

Molecular Mechanism That Makes Immune System's Guard Dogs Howl

by VR Sreeraman on August 4, 2007 at 2:19 PM
Font : A-A+

Molecular Mechanism That Makes Immune System's Guard Dogs Howl

Researchers have found the molecular mechanism that helps toll-like receptors, also known as the guard dogs of the immune system, activate the body's defences.

Toll-like receptors, a class of proteins sniff out bacteria and viruses and activate the body's immune system for an attack on these invaders.


One of the proteins in this class, toll-like receptor 9 or TLR9, can pick up a snippet of DNA common in bacteria and viruses called CpG DNA.

The study could help drug makers create DNA-based drugs which would get the guard dogs howling, which, in turn, would trip a fast immune response, causing the body to attack cancerous tumours or, if used as an ingredient in vaccines, bolster the assault on infectious diseases such as hepatitis B and C. CpG DNA could even be used to treat immune system disorders such as asthma and allergies.

The study was conducted by a ream of researchers led by Wen-Ming Chu at Brown University

Researchers found a direct interaction between HMGB1, (a protein released when infection occurs, when cells are damaged or when tissue is injured) and TLR9.

The study found that when the invader's DNA is present TLR9 meets up with HMGB1. The combination occurs inside tiny cellular cargo boxes, called endoplasmic reticulum-Golgi intermediate compartments (ERGIC).

Researchers noted that in ERGIC the proteins bind to form a complex that sets off a biochemical cascade, which triggers the body's immune response.

When HMGB1 is absent from cells, it was found that the body's immune response was significantly delayed.

Source: ANI


Recommended Readings

Latest Research News

Is There a Cure for Malaria Through Targeting Biological Clocks?
Malaria parasites sync their molecular rhythms with the internal 24-hour clocks of their hosts, said researchers.
Good Evenings Recovery Leads to Better Work Days
A latest research suggests that the quality of a person's post-work recovery in the evening can impact their mood when they resume work the next day.
Link Between Sleep Apnea and Cognitive Decline
Researchers are working on new strategies and solutions for sleep apnea to ward off a range of health risks including cognitive decline.
Softening Stem Cells Enhances Hair Growth Potential
The scientists discovered that when the stem cells in the hair follicle are made softer, they have a higher chance of growing hair.
Potential New Strategy for Ischemic Stroke Discovered
A combinatorial therapy provided promising beneficial results among people with ischemic stroke.
View All
This site uses cookies to deliver our services.By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use  Ok, Got it. Close

Molecular Mechanism That Makes Immune System's Guard Dogs Howl Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests