About Careers MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

Modern Drug Development Use NMR for Purification

by Rathi Manohar on September 30, 2010 at 6:56 PM
Font : A-A+

 Modern Drug Development Use NMR for Purification

Modern drug development faces a problem in separating proteins from deadly impurities in the purification process.

Scientists within the Center for Biotechnology and Interdisciplinary Studies (CBIS) at Rensselaer Polytechnic Institute are using nuclear magnetic resonance (NMR) to understand and improve an important protein purification process.

Advertisement

"We hope to use our insights to help those in the industry develop improved processes to provide much less expensive drugs and dramatically reduce healthcare costs," said paper author and William Weightman Walker Professor of Polymer Engineering Steven Cramer of Rensselaer.

His team's findings are published in the Sept. 2 online early edition of the journal Proceedings of the National Academy of Sciences (PNAS ) in a paper titled "Evaluation of protein absorption and preferred binding regions in multimodal chromatography using NMR." The research was funded by the National Science Foundation (NSF).
Advertisement

The process of multimodal chromatography has recently generated significant interest in the pharmaceutical industry. At its most basic, this process separates proteins from their surrounding materials, such as DNA and other proteins. The process works by encouraging the desired protein to stick to a material that contains a ligand, a type of molecular glue. Each ligand is only attracted to certain parts of certain proteins. Having been separated from the mixture, the specific protein can now be obtained in purer form, facilitating its eventual use as a biotherapeutic.



Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
World AIDS Day 2022 - Equalize!
Test Your Knowledge on Sugar Intake and Oral Health
Test  Your Knowledge on Heart
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Drug Toxicity Signature Drug Toxicity 

Most Popular on Medindia

Indian Medical Journals Hearing Loss Calculator Drug - Food Interactions Noscaphene (Noscapine) Blood Pressure Calculator Turmeric Powder - Health Benefits, Uses & Side Effects Blood - Sugar Chart Daily Calorie Requirements Diaphragmatic Hernia Find a Hospital
This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
×

Modern Drug Development Use NMR for Purification Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests