Medindia LOGIN REGISTER
Medindia
Advertisement

Mirabegron Effective and Well Tolerated for Overactive Bladder, Says Research

by Kathy Jones on March 5, 2013 at 8:45 PM
 Mirabegron Effective and Well Tolerated for Overactive Bladder, Says Research

There is an urgent need for new therapies for overactive bladder.

In a new phase III trial mirabegron, a β3-adrenoceptor agonist, given once daily for 12 weeks, reduced the frequency of incontinence episodes and number of daily urinations, and improved urgency and nocturia in adults with overactive bladder (OAB) compared to those in a placebo group. The incidence of common adverse events (hypertension, urinary tract infection, headache, nasopharyngitis) was similar in the mirabegron and placebo groups in this study. Rates of dry mouth and constipation were similar in the drug and placebo groups. The study is published in the Journal of Urology®.

Advertisement

"Mirabegron is a first in class therapeutic agent with a mechanism of action distinct from that of antimuscarinic agents," says urologist Victor W. Nitti, MD, of the NYU Langone Medical Center. "While antimuscarinic agents are the current pharmacological mainstay for OAB, some patients have a suboptimal response or experience side effects such as dry mouth or constipation. The result is that a high proportion of patients on antimuscarinic drugs discontinue therapy, with only 25% remaining on therapy at one year. We need an alternative therapy for some of these patients."

This randomized, parallel group, double-blind phase III study comprising 1329 patients was conducted at 132 sites in the U.S. and Canada. Those eligible for the study voided 8 or more times daily and experienced 3 or more urgency episodes with or without incontinence over a 3-day period. After 2 weeks of receiving placebo, 454 patients were randomized to continue to receive placebo, 442 were given 50 mg mirabegron and 433 received 100 mg mirabegron daily for 12 weeks.
Advertisement

Compared to the placebo group, both mirabegron treatment groups showed statistically significant (p <0.05) reductions from baseline to final visit in the mean number of incontinence episodes and micturitions per 24 hours. Interestingly, the voided volume per micturition more than doubled, from an average of 7.0 ml/micturition to about 18 ml/micturition in the mirabegron groups. This finding supports the hypothesis that unlike antimuscarinic drugs, β3-adrenergic agonists work by promoting urine storage and increasing bladder capacity, according to the authors.

Urgency and nocturia were reduced in those treated with mirabegron compared to placebo. Significant improvements were seen in quality of life measures, and the magnitude of the treatment response was similar to that seen with other OAB agents.

The frequency of dry mouth was low and similar in all groups. Two percent or fewer of each group reported constipation. No significant differences were noted among the groups for any other treatment-emergent adverse event, including acute urinary retention, cardiac arrhythmia, or hypertension, and there were no significant hematologic or serum chemistry abnormalities.

"With its balanced efficacy, safety, and tolerability profile, mirabegron could provide an alternative therapeutic option for OAB, particularly in patients whose OAB is inadequately addressed by current antimuscarinic therapy," says Dr. Nitti.



Source: Eurekalert
Font : A-A+

Advertisement

Advertisement
Advertisement

Latest Research News

AI Shows Promise in Identifying ADHD
The AI method shows promise in identifying imaging biomarkers for diagnosing ADHD.
Life Expectancy Gap for Autistic Individuals Revealed
Diagnosed autistic individuals showed increased premature mortality in the UK, highlighting urgent needs to address associated inequalities.
Exploring How Hearing Impairment Shapes Dementia Risk
Study reveals a correlation between hearing impairment and distinct brain region variances, contributing to dementia.
Coffee and its Role in Neurodegenerative Disorders
Financial impact of caring for individuals with neurodegenerative disorders reaches hundreds of billions annually in the United States.
Healthcare Industry Struggles With Tech Skills Shortage
Experts emphasize that addressing the skills gap demands immediate attention and innovative solutions, including education, re-training, and significant time investment.
View All
This site uses cookies to deliver our services.By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use  Ok, Got it. Close
×

Mirabegron Effective and Well Tolerated for Overactive Bladder, Says Research Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests