About Careers Internship MedBlog Contact us

MicroRNA That Controls Blood Vessel Development Identified

by Rajashri on August 12, 2008 at 5:50 PM
 MicroRNA That Controls Blood Vessel Development Identified

A key regulatory factor that controls development of the human vascular system-the extensive network of arteries, veins, and capillaries that allow blood to reach all tissues and organs has been identified by an Indian-origin researcher.

Dr. Deepak Srivastava, the Director of the Gladstone Institute of Cardiovascular Disease (GICD), says that this advancement by researchers from the Gladstone Institute of Cardiovascular Disease (GICD) and UCSF attains significance because it may offer clues to potential therapeutic targets for diseases like heart disease or cancer, which are impacted by or affect the vascular system.


Working with colleagues from the University of California, San Francisco (UCSF), he has discovered that microRNA (miR-126), a tiny RNA molecule, is intimately involved in the response of blood vessels to angiogenic signals.

A research article in the journal Developmental Cell describes Angiogenesis as the process of vascular development.

A cascade of genes orchestrate a series of events leading to formation of blood vessels in an embryo.

"Some of these same gene regulatory networks are re-activated in the adult to direct the growth of new blood vessels. This can be beneficial, as in the case of a heart attack," said Dr. Jason Fish, lead author of the study.

The researcher further said that blood vessel formation could also contribute to disease in settings like cancer, where vessels feed a growing tumour.

"Finding that a single factor regulates a large part of the angiogenic process creates a significant target for therapeutic development for any disease involving the vascular system," said Dr. Srivastava.

"The next step is to find ways to modify this microRNA in the setting of disease and test its ability to alter the disease process," he added.

Source: ANI
Font : A-A+



Recommended Readings

Latest Research News

Unlocking the Gut Microbiome's Influence on Bone Density
Scientists aim to pinpoint particular functional pathways affected by these bacteria that may have an impact on skeletal health.
Hop-Derived Compound Reduces Gut Microbe Linked to Metabolic Syndrome
Consuming a diet rich in saturated fats triggers persistent, low-level inflammation within the body, ultimately contributing to the onset of metabolic syndrome.
Breakthrough in Mosquitoes for Fighting Dengue Fever
Ae. aegypti mosquitoes are carriers of "arthropod-borne" or "arbo-" viruses, which encompass the dengue virus, yellow fever virus, Zika virus, and chikungunya virus.
Cerebrospinal Fluid Leaks: Link to Traumatic Brain Injury and Dementia?
Cerebrospinal fluid (CSF) leaks are detected in approximately 1-3% of adults who have experienced a traumatic brain injury.
Astrocyte Activation Through Optogenetics: A New Hope in the Fight Against Alzheimer's
The optogenetic activation of hippocampal astrocytes can be viewed as a novel therapeutic avenue for addressing Alzheimer's disease.
View All
This site uses cookies to deliver our services.By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use  Ok, Got it. Close
Greetings! How can I assist you?MediBot

MicroRNA That Controls Blood Vessel Development Identified Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests