A key regulatory factor that controls development of the human vascular system-the extensive network of arteries, veins, and capillaries that allow blood to reach all tissues and organs has been identified by an Indian-origin researcher.
Dr. Deepak Srivastava, the Director of the Gladstone Institute of Cardiovascular Disease (GICD), says that this advancement by researchers from the Gladstone Institute of Cardiovascular Disease (GICD) and UCSF attains significance because it may offer clues to potential therapeutic targets for diseases like heart disease or cancer, which are impacted by or affect the vascular system.
Brain Tumor
Brain tumors are the abnormal growth of brain cells that may be benign or metastatic. Brain tumors account for about 2.4% of all the tumor diagnosesandare most challenging due to their critically delicate location.
Advertisement
Working with colleagues from the University of California, San Francisco (UCSF), he has discovered that microRNA (miR-126), a tiny RNA molecule, is intimately involved in the response of blood vessels to angiogenic signals.
A research article in the journal Developmental Cell describes Angiogenesis as the process of vascular development.
A cascade of genes orchestrate a series of events leading to formation of blood vessels in an embryo.
![Protein Linked to Brain Disease Deciphered at Atomic Level]( "Protein Linked to Brain Disease Deciphered at Atomic Level")
For the first time, Ohio State University researchers have taken an atomic-level look at the protein that causes hereditary cerebral amyloid angiopathy (CAA) - a disease thought to
"Some of these same gene regulatory networks are re-activated in the adult to direct the growth of new blood vessels. This can be beneficial, as in the case of a heart attack," said Dr. Jason Fish, lead author of the study.
The researcher further said that blood vessel formation could also contribute to disease in settings like cancer, where vessels feed a growing tumour.
"Finding that a single factor regulates a large part of the angiogenic process creates a significant target for therapeutic development for any disease involving the vascular system," said Dr. Srivastava.
"The next step is to find ways to modify this microRNA in the setting of disease and test its ability to alter the disease process," he added.
Source: ANI
RAS/L
A cascade of genes orchestrate a series of events leading to formation of blood vessels in an embryo.
Protein Linked to Brain Disease Deciphered at Atomic Level
For the first time, Ohio State University researchers have taken an atomic-level look at the protein that causes hereditary cerebral amyloid angiopathy (CAA) - a disease thought to
Advertisement
"Some of these same gene regulatory networks are re-activated in the adult to direct the growth of new blood vessels. This can be beneficial, as in the case of a heart attack," said Dr. Jason Fish, lead author of the study.
The researcher further said that blood vessel formation could also contribute to disease in settings like cancer, where vessels feed a growing tumour.
"Finding that a single factor regulates a large part of the angiogenic process creates a significant target for therapeutic development for any disease involving the vascular system," said Dr. Srivastava.
"The next step is to find ways to modify this microRNA in the setting of disease and test its ability to alter the disease process," he added.
Source: ANI
RAS/L
Advertisement
Advertisement
|
Advertisement
Recommended Readings
Latest Research News
Scientists aim to pinpoint particular functional pathways affected by these bacteria that may have an impact on skeletal health.
Consuming a diet rich in saturated fats triggers persistent, low-level inflammation within the body, ultimately contributing to the onset of metabolic syndrome.
Ae. aegypti mosquitoes are carriers of "arthropod-borne" or "arbo-" viruses, which encompass the dengue virus, yellow fever virus, Zika virus, and chikungunya virus.
Cerebrospinal fluid (CSF) leaks are detected in approximately 1-3% of adults who have experienced a traumatic brain injury.
The optogenetic activation of hippocampal astrocytes can be viewed as a novel therapeutic avenue for addressing Alzheimer's disease.
