MicroRNA Delivery Using Magnetic Micro Metal Beads may Help Treat Constipation

by Anjali Aryamvally on  January 17, 2018 at 12:48 PM Research News
RSS Email Print This Page Comment bookmark
Font : A-A+

Using a new technique to deliver gene-therapy-like intervention directly where it's needed, a research team at Thomas Jefferson University successfully increased or decreased the muscle tone of the anal sphincter in appropriate animal models. These studies could have implications in treating constipation or incontinence. The study is published in the American Journal of Physiology-Gastrointestinal and Liver Physiology.
MicroRNA Delivery Using Magnetic Micro Metal Beads may Help Treat Constipation
MicroRNA Delivery Using Magnetic Micro Metal Beads may Help Treat Constipation

Constipation is an underestimated and debilitating medical issue related to the opioid epidemic. As a growing concern, researchers look to new tools to help patients with this side effect of opioid use and aging.

Show Full Article


Both constipation and incontinence, although multifactorial, have also been associated with the problems related to the regulation of a ring of smooth muscle around the anal opening termed, the internal anal sphincter. Unlike the way we can clench muscles just by thinking about them, smooth muscle is a type of muscle that we can't control with our thoughts. Dr. Satish Rattan, Professor in the Department of Medicine, Division of Gastroenterology and Hepatology at Jefferson's Sidney Kimmel Medical College, together with Drs. Jagmohan Singh and Ipsita Mohanty, used altered copies of the body's own genetic make-up - small RNA fragments (microRNAs) that regulate the target gene RhoA/ROCK - in order to strengthen or weaken the muscle tone of the sphincter. (Dr. Rattan's lab had shown earlier that changing RhoA/ROCK gene expression could alter smooth muscle tone.) But rather than simply inject the agent, where it could have spread through the tissue to affect other regions, the investigators kept the microRNAs localized to the ring of muscle. They did this by first injecting the microRNAs mixed with micro metal beads, and then kept them localized to the sphincter with a magnet. This innovative yet simple approach was more effective at keeping the microRNAs in the right place than injecting the microRNAs alone.

Because sphincters also help keep food in the stomach from rising up the esophagus, using a similar approach has additional implications in the lower esophageal sphincter where its localized stimulation could help prevent acid reflux in difficult-to-treat cases. First, however, the researchers will have to demonstrate whether the same principals hold true in humans, without side effects.



Source: Eurekalert

Post a Comment

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
Notify me when reply is posted
I agree to the terms and conditions

Recommended Reading

News A - Z

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

News Search

Premium Membership Benefits

Medindia Newsletters

Subscribe to our Free Newsletters!

Terms & Conditions and Privacy Policy.

Stay Connected

  • Available on the Android Market
  • Available on the App Store

News Category

News Archive